92592-02-4

Basic information

• Product Name: ethyl2-(2-benzyloxycarbonylaMinothiazol-4-yl)acetate
• Synonyms: ethyl2-(2-benzyloxycarbonylaMinothiazol-4-yl)acetate
• CAS NO: 92592-02-4
• Molecular Formula: C₁₅H₁₆N₂O₄S
• Molecular Weight: 320.36354
• Mol File: 92592-02-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.326±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.87±0.70(Predicted)
• CAS DataBase Reference: ethyl2-(2-benzyloxycarbonylaMinothiazol-4-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl2-(2-benzyloxycarbonylaMinothiazol-4-yl)acetate(92592-02-4)
• EPA Substance Registry System: ethyl2-(2-benzyloxycarbonylaMinothiazol-4-yl)acetate(92592-02-4)

Safety Data

• Hazardous Substances Data: 92592-02-4(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Upstream product

• 53266-94-7 ethyl 2-amino-1,3-thiazol-4-acetate 
• 501-53-1 benzyl chloroformate 

Relevant articles and documents

The Chemistry of Some 2-Aminothiazol-4-ylacetic Acid Derivatives and the Synthesis of Derived Penicillins

The N-protected 2-aminothiazol-4-ylacetic acid derivatives (6), (11), (14), (16), (18), (26), (27), (30), (33), and (34) have been prepared.They are readily available by reaction of the corresponding 2-aminoethyl esters such as (1) with the appropriate acylating agents, generally giving a bis-carbamate of type (5), followed by saponification.The process is general for α-methylene, α-oximino, and α-aminosubstituents in the side-chain affording in the last case a route to differentially protected α-amino-α-(2-aminothiazol-4-yl)acetic acids such as (30).The optimum conditions for the acylations are described; the course of the saponification of the bis-carbamate esters is discussed and physical evidence for the structures of the derivatives is presented.The use of the protected acids (11) and (34) in the synthesis of the piperacillin analogue (38) is described.