92357-95-4

Basic information

• Product Name: 10-(3-BroMopropyl)-10H-phenothiazine
• Synonyms: 10-(3-BroMopropyl)-10H-phenothiazine;10-(3-BroMopropyl)phenothiazine
• CAS NO: 92357-95-4
• Molecular Formula: C₁₅H₁₄BrNS
• Molecular Weight: 320.24736
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 92357-95-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Diethyl Ether, Ethyl Acetate
• CAS DataBase Reference: 10-(3-BroMopropyl)-10H-phenothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 10-(3-BroMopropyl)-10H-phenothiazine(92357-95-4)
• EPA Substance Registry System: 10-(3-BroMopropyl)-10H-phenothiazine(92357-95-4)

Safety Data

• Hazardous Substances Data: 92357-95-4(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 92-84-2 10H-phenothiazine 
• 109-64-8 1,3-dibromo-propane 
• 81055-36-9 1-bromo-3-(toluene-4-sulfonyloxy)propane 

Downstream Products

• 84-97-9 Perazin 
• 110435-59-1 10-<3-(Aethyl-piperazino)-propyl>-phenthiazin. 
• 97921-94-3 10-[3-(4-isopropyl-piperazin-1-yl)-propyl]-10H-phenothiazine 
• 47621-82-9 [2-(2-methoxy-phenoxy)-ethyl]-(3-phenothiazin-10-yl-propyl)-amine 
• 101199-34-2 3-(10-phenothiazinyl)propyltriethylammonium bromide 
• 101199-38-6 sodium 3-(10'-phenothiazinyl)propane-1-sulfonate 
• 103331-66-4 N.N'-Bis-<3-(phenthiazinyl-(10))-propyl>-piperazin. 
• 101199-36-4 3-(10-phenothiazinyl)propyltriethylammonium chloride 
• 1005214-98-1 C₃₉H₄₀N₂O₄S 
• 1169982-57-3 C₂₅H₂₃NO₅S 

Relevant articles and documents

Solvent effects on photosensitized splitting of thymine cyclobutane dimer by an attached phenothiazine

The splitting quantum yields of the dimer by tethered chromophores exhibited different solvent effects. To further explore mechanism of the solvent effects, three covalently linked phenothiazine-dimer model compounds with a short linker, 1a-1c, were prepared. It was observed that solvent effect on dimer-splitting efficiency for phenothiazine-dimer systems is contrary to that of the other chromophore-dimer systems. Calculated results based on the Marcus theory showed that phenothiazine systems with a lower driving force induced by a lower value of Eox have a longer donor-acceptor distance between phenothiazine moiety and dimer unit, then gives a higher λs. Thus, back electron transfer would lie in the Marcus normal region for phenothiazine-dimer models, in which dimer-splitting is more efficient in higher polarity solvents. The value of redox potential between a donor and an acceptor should be a key leading to back electron transfer lying in the different Marcus regions and following two reverse solvent effects. Moreover, fluorescence spectra showed that the dual fluorescence gives a hint of charge-transfer complexes, and partial charge transfer would lead to lower splitting efficiency. However, some new insights into mechanisms of DNA photoreactivation mediated by photolyases were gained.

PROTEOLYSIS TARGETING CHIMERIC (PROTAC) COMPOUND WITH E3 UBIQUITIN LIGASE BINDING ACTIVITY AND TARGETING ALPHA-SYNUCLEIN PROTEIN FOR TREATING NEURODEGENERATIVE DISEASES

The present disclosure relates to bifunctional compounds, which find utility as modulators of alpha-synuclein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/ inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure. Such diseases or disorders are alpha-synucleinopathies or neurodegenerative diseases associated with alpha-synuclein accumulation and aggregation, such as e.g. Parkinson Disease, Alzheimer's Disease, dementia, dementia with Lewy bodies or multiple system atrophy, in particular Parkinson's Disease.

UiO-68-PT MOF-Based Sensor and Its Mixed Matrix Membrane for Detection of HClO in Water

As an important type of reactive oxygen species (ROS), hypochloric acid (HClO) is closely linked with our daily life, and its convenient and rapid detection is very significant and imperative. Fluorescent and visual probes are being recognized as powerful and convenient tools for detection of ROS in the environment and living organisms by visualizing and imaging. In this contribution, a new metal-organic framework-based fluorescent probe UiO-68-PT, which was generated from a phenthiazine-decorated benzimidazole bridging dicarboxyl ligand and ZrCl4 under solvothermal conditions via in situ one-pot approach, is reported. The obtained UiO-68-PT features a unique HClO and Vitamin C-triggered reversible redox process, which is accompanied by both visual and fluorescence changes. Therefore, it can be a highly sensitive, specific, and reusable sensor to detect HClO species in water via both visual and fluorogenic observation (turn-on). Furthermore, its mixed membrane material (MMM) was fabricated by the combination of UiO-68-PT and poly(vinyl alcohol), and the obtained hydrophilic MMM can be used as a reversible colorimetric card for visual detection of the HClO in aqueous solution.