Welcome to LookChem.com Sign In|Join Free

CAS

  • or

92077-78-6

Cilazapril is a potent and long-lasting angiotensin-converting enzyme (ACE) inhibitor, used in the management of mild to moderate hypertension. It is a prodrug that is de-esterified to its active diacid metabolite cilazaprilat upon oral administration. Cilazapril is characterized by its white or almost white crystalline powder form and exhibits more potency and longer duration of action compared to other ACE inhibitors like enalapril and captopril.

92077-78-6 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 92077-78-6 Structure

  • Basic information

    1. Product Name: CILAZAPRIL
    2. Synonyms: Initiss;Justor;Vascase;9-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-10-oxo-1,2,3,4,6,7,8,9-oc tahydropyridazino[1,2-a]diazepine-1-carboxylic acid;(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid hydrate;(1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}-1-hydroxy-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid;Cilazapril Monohydrate (Inhibace);6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]octahydro-10-oxo-,hydrate (1:1), (1S,9S)-
    3. CAS NO:92077-78-6
    4. Molecular Formula: C22H33N3O6
    5. Molecular Weight: 435.51
    6. EINECS: 200-258-5
    7. Product Categories: Inhibitors
    8. Mol File: 92077-78-6.mol
    9. Article Data: 0

  • Chemical Properties

    1. Melting Point: 98° (dec)
    2. Boiling Point: 598.1 °C at 760 mmHg
    3. Flash Point: 315.5 °C
    4. Appearance: /
    5. Density: N/A
    6. Vapor Pressure: 3.73E-15mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: N/A
    9. Solubility: Slightly soluble in water, freely soluble in methanol and in methylene chloride.
    10. PKA: pKa1 3.3; pKa2 6.4(at 25℃)
    11. CAS DataBase Reference: CILAZAPRIL(CAS DataBase Reference)
    12. NIST Chemistry Reference: CILAZAPRIL(92077-78-6)
    13. EPA Substance Registry System: CILAZAPRIL(92077-78-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 92077-78-6(Hazardous Substances Data)

92077-78-6 Usage

Uses

Used in Pharmaceutical Industry:
Cilazapril is used as an antihypertensive agent for the treatment of mild to moderate hypertension. It functions by inhibiting the angiotensin-converting enzyme, which in turn reduces the production of angiotensin II, a potent vasoconstrictor. This leads to vasodilation, decreased peripheral resistance, and ultimately, a reduction in blood pressure.
The use of Cilazapril in the pharmaceutical industry is primarily for its therapeutic effects in managing hypertension, providing a more potent and longer-lasting alternative to other ACE inhibitors. Its chemical properties and mode of action make it a valuable component in the development of antihypertensive medications.

Check Digit Verification of cas no

The CAS Registry Mumber 92077-78-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,0,7 and 7 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 92077-78:
(7*9)+(6*2)+(5*0)+(4*7)+(3*7)+(2*7)+(1*8)=146
146 % 10 = 6
So 92077-78-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H31N3O5.H2O/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26;/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28);1H2/t17-,18-,19-;/m0./s1

92077-78-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Sigma-Aldrich

  • (C2174000)  Cilazapril  European Pharmacopoeia (EP) Reference Standard

  • 92077-78-6

  • C2174000

  • 1,880.19CNY

  • Detail

92077-78-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name CILAZAPRIL

1.2 Other means of identification

Product number -
Other names Cilazapril Monohydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:92077-78-6 SDS

92077-78-6Upstream product

92077-78-6Downstream Products

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 92077-78-6