92-80-8

Basic information

• Product Name: 2-HYDROXY-3-NAPHTHOIC ACID ETHANOLAMIDE
• Synonyms: 2-HYDROXY-3-NAPHTHOIC ACID ETHANOLAMIDE;3-HYDROXY-2-NAPHTHOIC ACID, N-(2-HYDROXYETHYL)AMIDE;3-HYDROXY-N-(2-HYDROXYETHYL)-2-NAPHTHAMIDE;3-hydroxy-N-(2-hydroxyethyl)naphthalene-2-carboxamide;2-Hydroxy-3-[(2-hydroxyethyl)carbamoyl]naphthalene;2-Hydroxy-3-naphthoic acid-N-ethanoylamide;3-Hydroxy-N-(2-hydroxyethyl)-2-naphthalenecarboxamide;3-Hydroxy-N-(2-hydroxyethyl)-2-napthamide
• CAS NO: 92-80-8
• Molecular Formula: C₁₃H₁₃NO₃
• Molecular Weight: 231.25
• EINECS: 202-191-8
• Mol File: 92-80-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 134 °C
• Boiling Point: 520.1°C at 760 mmHg
• Flash Point: 268.3°C
• Appearance: /
• Density: 1.311g/cm³
• Vapor Pressure: 1.21E-11mmHg at 25°C
• Refractive Index: 1.668
• PKA: 8.78±0.40(Predicted)
• CAS DataBase Reference: 2-HYDROXY-3-NAPHTHOIC ACID ETHANOLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3-NAPHTHOIC ACID ETHANOLAMIDE(92-80-8)
• EPA Substance Registry System: 2-HYDROXY-3-NAPHTHOIC ACID ETHANOLAMIDE(92-80-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 92-80-8(Hazardous Substances Data)

Usage

Description

2-HYDROXY-3-NAPHTHOIC ACID ETHANOLAMIDE is a chemical compound synthesized from the reaction between 2-hydroxy-3-naphthoic acid and ethanolamine. It is characterized by its potential as a pharmaceutical intermediate and its applications in the development of medicinal products, particularly in the realms of anti-inflammatory and analgesic drugs.

Uses

Used in Pharmaceutical Industry:
2-HYDROXY-3-NAPHTHOIC ACID ETHANOLAMIDE is used as a pharmaceutical intermediate for the synthesis of various drugs and pharmaceutical compounds, leveraging its chemical properties to contribute to the development of new medications.
Used in Medicine Development:
In the field of medicine, 2-HYDROXY-3-NAPHTHOIC ACID ETHANOLAMIDE is used as a component in the formulation of anti-inflammatory and analgesic drugs, aiming to provide relief from pain and inflammation.
Used in Dye and Pigment Production:
2-HYDROXY-3-NAPHTHOIC ACID ETHANOLAMIDE may also be utilized in the production of dyes and pigments, capitalizing on its chemical structure to create colorants for various applications.
Used in Research and Development:
2-HYDROXY-3-NAPHTHOIC ACID ETHANOLAMIDE has potential uses in the research and development of other chemical and biological products, indicating its versatility and applicability in scientific innovation and exploration.

InChI:InChI=1/C13H13NO3/c15-6-5-14-13(17)11-7-9-3-1-2-4-10(9)8-12(11)16/h1-4,7-8,15-16H,5-6H2,(H,14,17)

Upstream product

• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 141-43-5 ethanolamine 
• 92-70-6 3-Hydroxy-2-naphthoic acid 

Downstream Products

• 75001-01-3 1-(4-diethylaminophenylazo)-3-(2-hydroxyethylcarbamoyl)-2-hydroxynaphthalene 

Relevant articles and documents

Identification of Adenosine Deaminase Inhibitors by Metal-binding Pharmacophore Screening

Adenosine deaminase (ADA) is a human mononuclear Zn2+ metalloenzyme that converts adenosine to inosine. ADA is a validated drug target for cancer, but there has been little recent work on the development of new therapeutics against this enzyme. The lack of new advancements can be partially attributed to an absence of suitable assays for high-throughput screening (HTS) against ADA. To facilitate more rapid drug discovery efforts for this target, an in vitro assay was developed that utilizes the enzymatic conversion of a visibly emitting adenosine analogue to the corresponding fluorescent inosine analogue by ADA, which can be monitored via fluorescence intensity changes. Utilizing this assay, a library of ～350 small molecules containing metal-binding pharmacophores (MBPs) was screened in an HTS format to identify new inhibitor scaffolds against ADA. This approach yielded a new metal-binding scaffold with a Ki value of 26±1 μM.

The influence of intramolecular hydrogen bonding on the order parameter and photostability properties of dichroic azo dyes in a nematic liquid crystal host

It has been demonstrated that intramolecular hydrogen bonding in two classes of dichroic azo dyes has a generally detrimental effect on order parameter in a nematic liquid crystal host. Derivatives of 4-(N,N- diethylamino)-4'-nitroazobenzene with hydroxy groups intramolecularly hydrogen bonded to the azo group show lower order parameters in E7 nematic liquid crystal than the parent dye, but higher order parameters than corresponding methoxy dyes. 1-Arylazo-2-naphthols with a hydrogen bonding carboxamide group in position 3 exist exclusively in the hydrazone form and show even lower order parameters. Intramolecular hydrogen bonding also has a deleterious effect on photochemical stability.