918898-11-0

Basic information

• Product Name: 5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one
• Synonyms: 5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one;5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)
• CAS NO: 918898-11-0
• Molecular Formula: C₇H₃Cl₂N₃O
• Molecular Weight: 216
• EINECS: 1312995-182-4
• Mol File: 918898-11-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.82
• CAS DataBase Reference: 5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one(918898-11-0)
• EPA Substance Registry System: 5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one(918898-11-0)

Safety Data

• Hazardous Substances Data: 918898-11-0(Hazardous Substances Data)

Usage

General Description

5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one is a chemical compound with the molecular formula C8H4Cl2N2O. It is a pyrimidine derivative with two chlorine atoms attached to the 5th and 7th positions of the pyrido ring. It is also known as NSC 78306 and is used in the field of medicinal chemistry for the development of pharmaceutical drugs. 5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one has been studied for its potential pharmacological properties, including its use as an anti-cancer agent and as an inhibitor of certain enzymes. Its unique structure makes it a promising candidate for further research and potential applications in the pharmaceutical industry.

Upstream product

• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 

Downstream Products

• 1391001-24-3 tert-butyl 4-(4-(7-chloro-3,4-dihydro-4-oxopyrido[4,3-d]pyrimidin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1390656-46-8 tert-butyl 4-(4-(7-(2,6-dichlorobenzyl)-3,4-dihydro-4-oxopyrido[4,3-d]pyrimidin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1390656-47-9 tert-butyl 4-(4-(7-(2,6-dichlorobenzyl)-1,2,3,4-tetrahydro-4-oxopyrido[4,3-d]pyrimidin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1390655-11-4 7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one 
• 1390656-45-7 5-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-7-chloropyrido[4,3-d]pyrimidin-4(3H)-one 
• 1391001-04-9 7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-4(3H)-one 
• 1263075-67-7 5-(2-(1H-pyrazol-4-yl)ethoxy)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one 
• 1263075-52-0 5-(5-(hydroxymethyl)thiophen-2-yl)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one 
• 1263077-37-7 5-chloro-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one 

Relevant articles and documents

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R1, R2, R3, X, Y, Z, A, B, G1, m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

BICYCLIC INHIBITORS OF ANAPHASTIC LYMPHOMA KINASE

Disclosed are compounds of formula (Ⅰ) and their pharmaceutical acceptable salts, wherein R1, R2, R3, X, Y, Z, A, B, G1, m and n are defined in the description. The compositions containing the said compounds used for inhibiting kinases such as anaphastic lymphoma kinase (ALK) and methods of treating diseases such as cancer are disclosed.