917507-80-3

Basic information

• Product Name: (2S,5S)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid
• Synonyms: (2S,5S)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid
• CAS NO: 917507-80-3
• Molecular Weight: 279.293
• Mol File: 917507-80-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2S,5S)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid(917507-80-3)
• EPA Substance Registry System: (2S,5S)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid(917507-80-3)

Safety Data

• Hazardous Substances Data: 917507-80-3(Hazardous Substances Data)

Upstream product

• 121895-18-9 (S)-2-amino-6-hydroxyhexanoic acid methyl ester hydrochloride 
• 44601-24-3 4-hydroxypentanal 
• 110-87-2 3,4-dihydro-2H-pyran 
• 117836-27-8 (2S,5R)-5-Hydroxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 824943-45-5 (2S,5R)-5-hydroxy-6-methoxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 227758-97-6 (2S)-3,4-dihydro-2H-pyridine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 154061-64-0 (2S)-2-<(Benzyloxycarbonyl)amino>-6-hydroxyhexanoic acid methyl ester 
• 117894-79-8 benzyl (1S,4S)-5-aza-2-oxa-3-oxobicyclo[2.2.2]octane-5-carboxylate 
• 501-53-1 benzyl chloroformate 
• 448964-01-0 (2S)-5-hydroxy-2-piperidinecarboxylic acid 
• 72180-34-8 (S)-5-Hydroxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 117836-22-3 (S)-5-Trimethylsilanyloxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 117836-20-1 (S)-2-Benzyloxycarbonylamino-5-(tert-butyl-dimethyl-silanyloxy)-6-chloro-hexanoic acid methyl ester 
• 117836-24-5 (S)-5-(tert-Butyl-dimethyl-silanyloxy)-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Downstream Products

• 63088-78-8 (2S,5R)-5-hydroxypiperidine-2-carboxylic acid 

Relevant articles and documents

MANUFACTURING METHOD OF (2S,5S)-5-HYDROXY-2-PIPERIDINECARBOXYLIC ACID AS WELL AS MANUFACTURING INTERMEDIATE OF THE SAME AND METHOD FOR MANUFACTURING THE SAME

PROBLEM TO BE SOLVED: To provide synthesis methods of 5-hydroxy-6-methoxypiperidine-2-carboxylic acid derivatives and 5-oxopiperidine-2-carboxylic acid derivatives more safely than ever by using inexpensive raw ingredients. SOLUTION: In the provided method, a compound expressed by the following formula [X] is manufactured from a compound expressed by the following formula [I] through steps (1) through (9) [either steps (4) and (5) or steps (6) and (7) in the case of steps (4) through (7)]. COPYRIGHT: (C)2015,JPOandINPIT

Diastereoselective synthesis of (2S,5S)- and (2S,5R)-N-benzyloxycarbonyl-5-hydroxypipecolic acids from trans-4-hydroxy-l-proline

An efficient diastereoselective synthesis of cis- and trans-5-hydroxy-(2S)-N-benzyloxycarbonyl pipecolic acids, starting from trans-4-hydroxy-l-proline is described. The key synthetic strategies involve the regioisomeric ring expansion of keto ester 8 and diastereoselective reduction of ketone 11 in high selectivity and yield.

CHIRAL SYNTHESIS OF 5-HYDROXY-(L)-PIPECOLIC ACIDS FROM (L)-GLUTAMIC ACID

A stereo- and enantio-specific synthesis of the naturally occuring cis-5-hydroxy-(L)-pipecolic acid (3) is described, starting from Z-(L)-glutamic acid; the key step involves cyclisation of a protected chlorohydrin, and also gives access to trans-5-hydroxy-(L)-pipecolic acid.