90905-32-1

Basic information

• Product Name: 2-METHOXY-PYRIMIDINE-5-CARBALDEHYDE
• Synonyms: ASISCHEM C63417;2-METHOXY-PYRIMIDINE-5-CARBALDEHYDE;5-PYRIMIDINECARBOXALDEHYDE, 2-METHOXY-;5-FORMYL-2-METHOXYPYRIMIDINE;5-Pyrimidinecarboxaldehyde, 2-methoxy- (9CI);2-Methoxy-5-pyrimidinecarbaldehyde;2-methoxypyrimidine-5-carbaldehyde(SALTDATA: FREE);2-Methoxypyrimidine-5-carboxaldehyde
• CAS NO: 90905-32-1
• Molecular Formula: C₆H₆N₂O₂
• Molecular Weight: 138.12
• Product Categories: PYRIMIDINE;Aldehyde;Building Blocks;Pyrimidines;Heterocycle-Pyrimidine series
• Mol File: 90905-32-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 281.261 °C at 760 mmHg
• Flash Point: 123.902 °C C
• Appearance: /
• Density: 1.238 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-METHOXY-PYRIMIDINE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-PYRIMIDINE-5-CARBALDEHYDE(90905-32-1)
• EPA Substance Registry System: 2-METHOXY-PYRIMIDINE-5-CARBALDEHYDE(90905-32-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 90905-32-1(Hazardous Substances Data)

Usage

Description

2-Methoxy-pyrimidine-5-carbaldehyde is a pyrimidine derivative with the molecular formula C6H6N2O2. It features a methoxy group and a carbaldehyde group attached to the 2 and 5 positions, respectively. This versatile chemical compound is widely used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and reactivity make it a valuable building block for the production of various drugs and compounds, contributing significantly to the field of chemical research and development.

Uses

Used in Pharmaceutical Industry:
2-Methoxy-pyrimidine-5-carbaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form diverse drug molecules. Its unique structure allows for the development of new therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Methoxy-pyrimidine-5-carbaldehyde is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its reactivity and structural features enable the creation of effective compounds for crop protection and management.
Used in Fine Chemicals Synthesis:
2-Methoxy-pyrimidine-5-carbaldehyde is employed as a building block in the synthesis of fine chemicals, including specialty chemicals and advanced materials. Its versatile reactivity allows for the development of novel compounds with specific properties for various applications.
Used in Organic Synthesis Research:
As a valuable compound in organic synthesis, 2-Methoxy-pyrimidine-5-carbaldehyde is used in research to explore new reaction pathways and develop innovative synthetic methods. Its unique properties and reactivity contribute to the advancement of chemical science and the discovery of new chemical entities.

InChI:InChI:1S/C6H6N2O2/c1-10-6-7-2-5(4-9)3-8-6/h2-4H,1H3

Upstream product

• 24285-39-0 methyl carbamimidate sulfate 
• 79-08-3 bromoacetic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 52328-05-9 O-methylisourea hemisulfate 
• 5329-33-9 o-methylisourea hydrochloride 
• 2440-60-0 2-methyl-isourea 
• 2009-81-6 2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate 
• 29427-58-5 O-methylisourea hemisulfate 

Downstream Products

• 120717-41-1 2-methoxy-5-vinylpyrimidine 
• 166757-62-6 2-hydroxypyrimidine-5-carbaldehyde 
• 1174506-55-8 5-((2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)-3-(2-methoxypyrimidin-5-yl)isoxazole 
• 943145-92-4 2-benzyloxycarbonylamino-3-(2-methoxy-pyrimidin-5-yl)-acrylic acid methyl ester 

Relevant articles and documents

HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES

The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Practical asymmetric synthesis of a non-peptidic αvβ 3 antagonist

(Chemical Equation Presented) The development of a practical and highly convergent synthesis of an αvβ3 antagonist is described. The two key fragments present in this compound, a tetrahydropyrido[2,3-b]azepine ring system and a chiral 3-aryl-5-oxopentanoic acid, were constructed independently and then coupled at a late stage using a Wittig reaction. The pyridoazepine moiety was prepared from N-Boc 6-chloro-2-aminopyridine via directed ortho-metalation/alkylation followed by in situ cyclization. A Suzuki reaction was then used to attach the propionaldehyde side-chain required for Wittig coupling. The coupling partner was prepared from asymmetric methanolysis of a 3-substituted glutaric anhydride followed by elaboration of the acid moiety to the requisite β-keto phosphorane. Using this route, kilogram quantities of the desired drug candidate were prepared.

Shock sensitivity of a vinamidinium bis-perchlorate reagent and demonstration of a lower energy alternative

'Vinamidinium' bis-perchlorate salt 1 (2-dimethylaminomethylene-1,3-bis(dimethylimmonio)-propane bis-perchlorate) was found to possess remarkably high thermal energy as well as significant shock sensitivity. A reported method for preparation of 2,5-disubstituted pyrimidines with 1 was of interest, and we found that the corresponding bis-tetrafluoroborate salt 2 was equally effective in this transformation, while possessing significantly lower thermal energy.