9002-60-2 Usage
Description
Corticotropin, also known as adrenocorticotropic hormone (ACTH), is a 39-amino-acid polypeptide hormone secreted by the anterior pituitary gland. It stimulates the adrenal cortex, boosting the synthesis of corticosteroids, primarily glucocorticoids, and also sex steroids (androgens). The physiological activity of corticotropin is found in the first 24 amino acids, which are common to many species, while most immunological activity lies in the remaining 15 amino acids. Corticotropin has a short half-life of 10 minutes, allowing for rapid adjustments in corticosteroid output.
Uses
Used in Hormone Therapy:
Corticotropin is used as a hormone, specifically an adrenocorticotropic hormone, to stimulate the adrenal cortex and increase the production of glucocorticoids.
Used in Diagnostic Aids:
Corticotropin is used as a diagnostic aid for investigating adrenocortical insufficiency, helping to identify issues with the adrenal cortex's ability to produce sufficient corticosteroids.
Used in Pharmaceutical Treatments:
Corticotropin is used in the treatment of certain neurological disorders, such as infantile spasms and multiple sclerosis, to manage symptoms and improve patient outcomes.
Used in Pharmaceutical Products:
Corticotropin is found in various pharmaceutical products, such as Acthar (Sanofi Aventis) and Cortrophin (Organon), which are used for the treatment of specific conditions and diagnostic purposes.
Used in Synthetic Corticotropins:
Synthetic corticotropins, which have shorter amino acid chains and lack amino acids 25-39, are used as an alternative to natural corticotropin. They are less likely to cause serious allergies and are devoid of animal proteins, which are potent allergens.
Used in Tetracosactide (Tetracosactrin):
Tetracosactide is a synthetic version of corticotropin that consists of the biologically active first 24 amino acids. It has similar properties to natural corticotropin, such as a half-life of 10 minutes, and is used for diagnostic and therapeutic purposes.
Used in Application Industry:
Corticotropin is used in the pharmaceutical industry for the development and production of medications and diagnostic tools to treat various conditions and investigate adrenal function.
Indications
Corticotropin (ACTH, Acthar, Cortrophin Gel) is an
open-chain polypeptide that consists of 39 amino acid
residues, the first 24 of which are essential for its biological
activity. The remainder of the amino acids are also
clinically important, since they may be involved in stimulating
antibody formation and causing allergic reactions.
This is true especially when corticotropin of animal
origin is injected into humans. Commercially available
corticotropin is prepared from animal pituitary glands.
Biological Activity
ACTH is the adrenocorticotropic hormone of the anterior lobe of the pituitary gland, which specifically stimulates the adrenal cortex to secrete cortisone, and hence has effects identical with those of cortisone. ACTH differs in its chemistry, absorption, and metabolism from the other adrenal steroids. Chemically, it is a watersoluble polypeptide having a molecular weight of about 3500. Its complete amino acid sequence has been determined. It produces its peripheral physiological effects by causing discharge of the adrenocortical steroids into the circulation. ACTH has been extracted from pituitary glands. In purified form, ACTH is useful in treating some forms of arthritis, lupus erythematosus, and severe skin disorders. The action of ACTH injections parallels the result of large quantities of naturally formed cortisone if they were released naturally.
Mechanism of action
Corticotropin stimulates the synthesis of corticosteroids (of which the most important is cortisol) and to a lesser extent of androgens, by the cells of the adrenal cortex. It has only a minor (transient) effect on aldosterone production, which proceeds independently; in the absence of corticotropin the cells of the inner cortex atrophy.
The release of natural corticotropin by the pituitary gland is controlled by the hypothalamus through corticotropin releasing hormone (CRH, or corticoliberin), production of which is influenced by environmental stresses as well as by the level of circulating cortisol. High plasma concentration of any adrenal steroid with glucocorticoid effect prevents release of CRH and so of corticotropin, lack of which in turn results in adrenocortical hypofunction. This is why catastrophe may accompany abrupt withdrawal of long-term adrenal steroid therapy with adrenal atrophy.
The effects of corticotropin are those of the steroids (hydrocortisone, androgens) liberated by its action on the adrenal cortex. Prolonged heavy dosage causes the clinical picture of Cushing's syndrome.
Pharmacology
Corticotropin is rapidly inactivated by gastrointestinal
proteolytic enzymes and therefore must be administered
parenterally. It is rapidly removed from the circulation
(T1/2, 15 minutes) and is probably inactivated in body tissues,
since no intact compound is found in the urine.
Clinical Use
The rationale for using corticotropin instead of pharmacological
concentrations of glucocorticoids stems
from the fact that corticotropin provides enhanced
amounts of all endogenously secreted adrenocortical
hormones, including androgens. However, obvious disadvantages
are associated with the use of this polypeptide:
(1) It must be given daily parenterally. (2) It is
quite expensive. (3) It is antigenic and thus can produce
resistance and hypersensitivity reactions. Corticotropin
is used as a diagnostic tool for the identification of primary
adrenal insufficiency or as a method for evaluating
the hypothalamic–pituitary–adrenal axis before surgery
in patients previously treated with glucocorticoids.
Clinical Use
Corticotropin is used principally in diagnosis and rarely in treatment. It is inactive if taken orally and has to be injected like other peptide hormones.
Diagnostic use is to test the capacity of the adrenal cortex to produce cortisol. With the short synacthen test, the plasma cortisol concentration is measured before and 30 min and 60 min after an intramuscular injection of 250 micrograms of tetracosactide (Synacthen); a normal response is a rise in plasma cortisol concentration of more than 200 nmol/L or a peak of greater than 500 nmol/L at 30 or 60 min. In cases of uncertainty, the longer variants of the test require intramuscular injection of a depot (sustained-release) formulation, e.g. 1 mg daily for 3 days at 09:00 hours, with a short tetracosactide test performed on day 3.
Therapeutic use is seldom appropriate, as the peptide hormone must be injected. Selective glucocorticoid (without mineralocorticoid) action is not possible, and clinical results are irregular. Corticotropin cannot be relied on to restore adrenal cortisol output when a steroid is being withdrawn after prolonged therapy, as it does not restore function in the suppressed hypothalamic–pituitary part of the HPA axis.
Side effects
Aside from hypersensitivity and allergic reactions, corticotropin
administration has been associated with electrolyte
disturbances and masculinization in women.
Veterinary Drugs and Treatments
Availability of corticotropin in FDA-approved products is an issue
as no commercially products were commercially available for veterinary
use at the time writing and either cosyntropin (see monograph)
or compounded ACTH products are required.
In veterinary medicine, an ACTH product (Adrenomone?—
Summit Hill) was approved
for use in dogs, cats, and beef or dairy
cattle for stimulation of the adrenal cortex when there is a deficiency
of ACTH and as a therapeutic agent in primary bovine ketosis,
but apparently is no longer commercially available. In practice,
ACTH tends to be used most often in the diagnosis of hyper- or
hypoadrenocorticism (ACTH-stimulation test) and to monitor the
response to mitotane therapy in Cushing’s syndrome.
One reference (Behrend 2003a) recommends using the ACTH
stimulation test if the dog has non-adrenal illness, received any
form of exogenous glucocorticoids (including topicals), or received
phenobarbital. If the dog has no known non-adrenal illness and
moderate to severe clinical signs of hyperadrenocorticism, use the
low-dose dexamethasone suppression test. If using the ACTH-stim
test, the author states that cosyntropin is the agent of choice (see
that monograph).
ACTH has been used for several purposes in human medicine
for its corticosteroid stimulating properties, but as it must be injected,
it is not commonly employed in veterinary patients.
Check Digit Verification of cas no
The CAS Registry Mumber 9002-60-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 9002-60:
(6*9)+(5*0)+(4*0)+(3*2)+(2*6)+(1*0)=72
72 % 10 = 2
So 9002-60-2 is a valid CAS Registry Number.
