900187-22-6Relevant articles and documents
Lysine sulfonamides as novel HIV-protease inhibitors: Nε-Acyl aromatic α-amino acids
Stranix, Brent R.,Lavallee, Jean-Francois,Sevigny, Guy,Yelle, Jocelyn,Perron, Valerie,LeBerre, Nicholas,Herbart, Dominik,Wu, Jinzi J.
, p. 3459 - 3462 (2007/10/03)
A series of lysine sulfonamide analogues bearing Nε-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.