89794-02-5

Basic information

• Product Name: 4-BROMO-2-CHLOROTOLUENE
• Synonyms: 4-BROMO-2-CHLOROTOLUENE;4-Bromo-2-chlorotoluene,98%;4-BroMo-2-chloro-1-Methylbenzene
• CAS NO: 89794-02-5
• Molecular Formula: C₇H₆BrCl
• Molecular Weight: 205.48
• Product Categories: Aromatic Halides (substituted);Halogen toluene;Bromine Compounds;Chlorine Compounds;Aryl;C7;Halogenated Hydrocarbons
• Mol File: 89794-02-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 43 °C
• Boiling Point: 212 °C(lit.)
• Flash Point: 220 °F
• Appearance: Clear pale yellow/Liquid
• Density: 1.54 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.167mmHg at 25°C
• Refractive Index: n20/D 1.574(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 3234853
• CAS DataBase Reference: 4-BROMO-2-CHLOROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-CHLOROTOLUENE(89794-02-5)
• EPA Substance Registry System: 4-BROMO-2-CHLOROTOLUENE(89794-02-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 89794-02-5(Hazardous Substances Data)

Usage

Description

4-Bromo-2-chlorotoluene is an organic compound derived from 4-bromo-2-nitrotoluene, characterized by its clear pale yellow liquid appearance. It is a halogenated aromatic compound with a bromine atom at the 4-position and a chlorine atom at the 2-position on the toluene ring.

Uses

Used in Chemical Synthesis:
4-Bromo-2-chlorotoluene is used as an intermediate in the synthesis of various organic compounds, particularly for the production of pharmaceuticals, agrochemicals, and specialty chemicals. Its unique halogenated structure allows for versatile chemical reactions, such as cross-coupling and nucleophilic substitution, making it a valuable building block in organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-bromo-2-chlorotoluene is used as a key intermediate for the synthesis of various drug molecules. Its presence in the molecular structure can impart specific biological activities and improve the pharmacokinetic properties of the final drug product.
Used in Agrochemical Industry:
4-Bromo-2-chlorotoluene is also utilized in the agrochemical industry for the development of new pesticides and herbicides. Its halogenated aromatic nature can contribute to the effectiveness of these agrochemicals in controlling pests and weeds.
Used in Specialty Chemicals:
In the specialty chemicals sector, 4-bromo-2-chlorotoluene is employed in the production of dyes, pigments, and other functional materials. Its unique chemical properties can enhance the performance and stability of these specialty chemicals in various applications.

InChI:InChI=1/C7H6BrCl/c1-5-2-3-6(8)4-7(5)9/h2-4H,1H3

Upstream product

• 1707-04-6 (3-chloro-4-methyl-phenyl)-phosphonic acid 
• 95-49-8 2-methylchlorobenzene 
• 106-38-7 para-bromotoluene 
• 119-32-4 4-Methyl-3-nitroanilin 

Downstream Products

• 59748-90-2 4-Bromo-2-chloro-benzoic Acid 
• 934989-14-7 1-bromo-5-chloro-2-iodo-4-methylbenzene 
• 91767-50-9 3-Chloro-4-methyl-benzoic acid butyl ester 
• 351995-40-9 C₁₁H₁₀ClNO₂ 

Relevant articles and documents

A new recoverable Au(III) catalyst supported on magnetic polymer nanocomposite for aromatic bromination

This Letter presents a facile alternative synthesis of a recoverable Au(III) catalyst supported on Fe3O4@SiO 2～MPS grafted by poly(N-vinyl-2-pyrrolidone) (PVP). The solid magnetic support was prepared by anchoring 3-methacryloxypropyltrimethoxysilane (MPS) onto the Fe3O4@SiO2 surfaces followed by free radical polymerization with N-vinyl-2-pyrrolidone. Au(III) was immobilized onto the magnetic support in aqueous media to afford Au(III)/Fe 3O4@SiO2～PVP (catalyst 1). Catalyst 1 was characterized by FT-IR, TEM, VSM, TGA, XRD, and ICP-AES. The amount of Au in catalyst 1 was measured to be 0.64 wt % by ICP-AES. This newly prepared catalyst can catalyze the aromatic bromination reaction with comparable activity as homogeneous AuCl3. Moreover, the supported catalyst is easy to recover and can be used in four cycles without apparent loss of activity.

Kinetics of nuclear chlorination of toluene and some substituted toluenes by trichloroisocyanuric acid

Nuclear chlorination of toluene and substituted toluenes by trichloroisocyanuric acid is first order each in and .The observed second order rate constants increase with increase in +> in solvent mixtures containing less than 50percent HOAc.The k2 values increase with an increase in the proportion of HOAc, reach maximum at 50percent HOAc above which the rate constants have a diminishing trend.At higher proportion of HOAc, the rate constants are insensitive to change in .Added Cl- ions enhance the rate.Based on the observed results a plausible mechanism has been proposed which envisages a positive ion dipole reaction between H+2OCl generated from hydrolysis of TCICA and the substrate molecules at low proportions of HOAc.At high proportion of HOAc, chlorine acetate has been suggested to be the electrophile.Molecular chlorine as well as H2O+Cl are the chlorinating species in the presence of Cl- ions.The Hammett plot is linear with a ρ value -5.55.The activation parameters have been computed.

Iminodimethylene di-tert-alkylophenones and phenols

Substituted-iminodimethylene-di-tert-alkylophenones, e.g., 4", 4"'-methyliminodimethylene-dipivalophenone, are prepared by treating a corresponding α-halo-p-tert-alkanoyl toluene with a substituted amine. The phenylcarbinols are prepared from the corresponding phenones and both the phenones and the phenylcarbinols are useful as hypolipidemic agents.