89640-55-1

Basic information

• Product Name: 3-IODO-4-METHOXY-PYRIDINE
• Synonyms: 3-IODO-4-METHOXY-PYRIDINE;Pyridine, 3-iodo-4-methoxy-
• CAS NO: 89640-55-1
• Molecular Formula: C₆H₆INO
• Molecular Weight: 235.02
• Mol File: 89640-55-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 271.2°C at 760 mmHg
• Flash Point: 117.8°C
• Appearance: /
• Density: 1.825g/cm³
• Vapor Pressure: 0.0109mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-IODO-4-METHOXY-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-4-METHOXY-PYRIDINE(89640-55-1)
• EPA Substance Registry System: 3-IODO-4-METHOXY-PYRIDINE(89640-55-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 89640-55-1(Hazardous Substances Data)

Usage

General Description

3-IODO-4-METHOXY-PYRIDINE is a chemical compound with the molecular formula C6H6INO. It is a dark red solid at room temperature and is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 3-IODO-4-METHOXY-PYRIDINE is an aromatic iodide and contains a methoxy group, making it useful in the production of various pharmaceuticals and agrochemicals. It is important to handle this compound with care as it is toxic if ingested or inhaled and can cause skin and eye irritation. Overall, 3-IODO-4-METHOXY-PYRIDINE is an important chemical in the production of various pharmaceuticals and agrochemicals, but should be handled with caution due to its toxicity.

InChI:InChI=1/C6H6INO/c1-9-6-2-3-8-4-5(6)7/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 89167-34-0 4-chloro-3-iodopyridine 
• 620-08-6 4-methoxypyridine 

Downstream Products

• 616-47-7 1-methyl-1H-imidazole 
• 1301610-35-4 tert-butyl (1-(4-((4-methoxypyridin-3-yl)ethynyl)phenyl)cyclobutyl)carbamate 
• 138207-05-3 Trifluoro-methanesulfonic acid 6-(3,4-dimethoxy-phenyl)-1,2,3,5,8,8a-hexahydro-indolizin-7-yl ester 
• 138207-11-1 3-(3,4-Dimethoxy-phenyl)-2-(3-hydroxy-propyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 138207-03-1 2-(3-Chloro-propyl)-5-(3,4-dimethoxy-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 138207-02-0 5-(3,4-Dimethoxy-phenyl)-2-(3-hydroxy-propyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 138207-04-2 6-(3,4-dimethoxyphenyl)-2,3,8,8a-tetrahydroindolizin-7(1H)-one 
• 26503-67-3 (+/-)-6,7-di(3,4-dimethoxyphenyl)-1,2,3,5,8,8a-hexahydro-indolizine 
• 138207-01-9 3-(3,4-Dimethoxy-phenyl)-4-methoxy-pyridine 

Relevant articles and documents

Copper-catalyzed trifluoromethylation of alkoxypyridine derivatives

The trifluoromethylation of aromatic and heteroaromatic cores has attracted considerable interest in recent years due to its pharmacological relevance. We studied the extension of a simple copper-catalyzed trifluoromethylation protocol to alkoxy-substituted iodopyridines and their benzologs. The trifluoromethylation proceeded smoothly in all cases, and the desired compounds were isolated and characterized. In the trifluoromethylation of 3-iodo-4-methoxyquinoline, we observed a concomitant O-N methyl migration, resulting in the trifluoromethylated quinolone as a product. Overall, the described procedure should facilitate the broader use of copper-catalyzed trifluoromethylation in medicinal chemistry.

Potassium-alkyl magnesiates: Synthesis, structures and Mg-H exchange applications of aromatic and heterocyclic substrates

Using structurally well-defined dipotassium-tetra(alkyl)magnesiates, a new straightforward methodology to promote regioselective Mg-H exchange reactions of a wide range of aromatic and heteroaromatic substrates is disclosed. Contacted ion pair intermediates are likely to be involved, with K being the key to facilitate the magnesiation processes. This journal is

Alkali-metal mediated zincation of N-heterocyclic substrates using the lithium zincate complex, (THF)Li(TMP)Zn(tBu)2 and applications in in situ cross coupling reactions

This study investigates the ability of the mixed-metal reagent [Li(TMP)Zn(tBu)2] 1 to promote direct Zn-H exchange reactions (zincations) of a wide range of N-heterocyclic molecules. The generated metallated intermediates from these reactions are intercepted with I2 and some of them are also employed as precursors in Pd-catalysed Negishi cross-coupling applications. A comparison with recent precedents in metallation chemistry reveals that for some of these heterocycles, 1 allows improved conversions, under milder conditions and in certain cases, even gives unique regioselectivities.