89639-98-5

Basic information

• Product Name: 2-Chloro-3-nitrobenzyl alcohol
• Synonyms: (2-CHLORO-3-NITROPHENYL)METHANOL;2-CHLORO-3-NITROBENZYL ALCOHOL;2-CHLORO-3-NITROPHENYLBENZYL ALCOHOL;2-hloro-3-nitrobenzyl alcohol
• CAS NO: 89639-98-5
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58
• Mol File: 89639-98-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 347.6 °C at 760 mmHg
• Flash Point: 164 °C
• Appearance: /
• Density: 1.476
• Vapor Pressure: 2.01E-05mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 2-Chloro-3-nitrobenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-nitrobenzyl alcohol(89639-98-5)
• EPA Substance Registry System: 2-Chloro-3-nitrobenzyl alcohol(89639-98-5)

Safety Data

• Hazardous Substances Data: 89639-98-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-nitrobenzyl alcohol is a chemical compound with the molecular formula C7H6ClNO3. It is a pale yellow solid that is used as an intermediate in the production of pharmaceuticals and agrochemicals. 2-Chloro-3-nitrobenzyl alcohol is commonly used in organic synthesis as a building block for the preparation of various organic compounds. It is also utilized as a reagent in the synthesis of various molecules with biological activity. 2-Chloro-3-nitrobenzyl alcohol has potential applications in the development of new drugs and in the research of organic chemistry.

InChI:InChI=1/C7H6ClNO3/c8-7-5(4-10)2-1-3-6(7)9(11)12/h1-3,10H,4H2

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 3970-35-2 2-chloro-3-nitrobezoic acid 
• 53663-14-2 anhydro-2-hydroxymercuri-3-nitrobenzoic acid 

Downstream Products

• 58755-57-0 2-chloro-3-nitrobenzaldehyde 
• 108772-93-6 2-chloro-3-nitrobenzyl chloride 
• 1428248-64-9 C₄₈H₄₄N₆O₉ 
• 1428248-55-8 (S)-2-amino-N-(2-(tert-butyldimethylsilyloxy)ethyl)-N-(2-chloro-3-nitrobenzyl)-3-(1H-indol-3-yl)propanamide 
• 1428248-54-7 2-(tert-butyldimethylsilyloxy)-N-(2-chloro-3-nitrobenzyl)ethanamine 
• 1192040-18-8 tert-butyl (2E)-3-(2-chloro-3-nitrophenyl)prop-2-enoate 
• 1192040-19-9 tert-Butyl 3-(3-amino-2-chlorophenyl)propanoate 
• 89642-16-0 α-bromo-2-chloro-3-nitrotoluene 
• 180080-64-2 N-(2-chloro-3-nitrophenylmethyl)iminodicarboxylic acid di-t-butyl ester 
• 108772-94-7 2,3-Bis-(2-chloro-3-nitro-phenyl)-propionitrile 
• 108772-95-8 2-chloro-3-nitrophenylacetonitrile 
• 112969-06-9 4-(2-chloro-3-nitrophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester 
• 866552-88-7 {2-(4-tert-butoxy-phenyl)-1-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(2-chloro-3-nitro-benzyl)-carbamoyl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 866552-89-8 {2-(4-tert-butoxy-phenyl)-1-[(2-chloro-3-nitro-benzyl)-(1-hydroxymethyl-2-methyl-butyl)-carbamoyl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

General synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor

The sulfoximine group has great potential as a substituent in drug discovery, as evidenced by two new clinical candidates, and can be viewed as an isosteric alternative to the commonly used sulfone. Our aim was to improve the accessibility of this group by synthesising a diverse range of S-alkyl and N-alkyl sulfoximine building blocks with procedures that are applicable on a practical scale (>10 g). In particular, synthesis of the less well exploited N-alkyl sulfoximines and the use of dimethylsulfoximine as a versatile, commercially available precursor is discussed.

Carbazole inhibitors of histamine receptors for the treatment of disease

The present invention relates to carbazole compounds, pharmaceutical compositions comprising them, and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

New benzodiazepine-based γ-turn mimetics with one or two amino acid side chains were synthesized. The γ-turn mimetics were incorporated into angiotensin II (Ang II) replacing the Val3-Tyr4-Ile 5 or Tyr4-Ile