89180-51-8

Basic information

• Product Name: 4-Amino-2,5-dichloropyrimidine
• Synonyms: 4-Amino-2,5-dichloropyrimidine;2,5-dichloropyrimidin-4-amine;2,5-dichloro-4-Pyrimidinamine;2,5-Dichloro-pyrimidin-4-ylamine
• CAS NO: 89180-51-8
• Molecular Formula: C₄H₃Cl₂N₃
• Molecular Weight: 163.995
• Mol File: 89180-51-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 343.475°C at 760 mmHg
• Flash Point: 161.528°C
• Appearance: /
• Density: 1.607g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.633
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-Amino-2,5-dichloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2,5-dichloropyrimidine(89180-51-8)
• EPA Substance Registry System: 4-Amino-2,5-dichloropyrimidine(89180-51-8)

Safety Data

• Hazardous Substances Data: 89180-51-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-2,5-dichloropyrimidine is used as a chemical intermediate for the synthesis of various pharmaceuticals. It plays a crucial role in the development of new drugs, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
4-Amino-2,5-dichloropyrimidine is used as a chemical intermediate for the synthesis of various agrochemicals. It aids in the production of effective pesticides and other agricultural chemicals, enhancing crop protection and yield.

InChI:InChI=1/C4H3Cl2N3/c5-2-1-8-4(6)9-3(2)7/h1H,(H2,7,8,9)

Upstream product

• 5750-76-5 2,4,5-trichloropyrimidine 

Relevant articles and documents

2-PHENYLAMINOPYRIMIDINE DERIVATIVES AS KINASE LRRK2 MODULATORS FOR THE TREATMENT OF PARKINSON'S DISEASE

Specific Compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein m, X, R, R2, R3, R, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

AMINOPYRIMIDINE DERIVATIVES AS LRRK2 INHIBITORS

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compound

IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES

The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors

A series of 5,7-disubstituted quinazolines, bearing 4-heteroaryl substituents such as 2-pyridinylamine or 2-pyrazinylamine, has been synthetised and evaluated as c-Src kinase inhibitors. Highly potent inhibition, high selectivity and physical properties suitable for oral dosing were achieved within this series: 23d and 42 were identified as sub-0.1 μM inhibitors in a c-Src-driven cell proliferation assay and displayed adequate rat pharmacokinetics after oral administration.

PYRIMIDIN-4-YL 3-CYANOQUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OF TUMOURS

The invention concerns quinoline derivatives of Formula I, Formula (I) wherein Z is an O, S, SO, SO2, N(R2) or C(R2)(R3) group wherein each R2 or R3 group is hydrogen or (1-8C)alkyl, m is 1, 2 or 3, each R1 group has any of the meanings defined in the description, Ra is hydrogen or halogeno, Rb is hydrogen, halogeno, (1-8C)alkyl or (1-6C)alkoxy, and Rd is (1-6C)alkoxy, or Ra and Rb together form a (1-3C)alkylenedioxy group, or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumor disease.

4-PYRIMIDINYL QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF TUMOURS

The invention concerns quinazoline derivatives of Formula (I) wherein Z is an O, S, SO, SO2, N (R2) or C (R2)(R3) group wherein each R2 or R3 group is hydrogen or (1-8C) alkyl, m is 1, 2 or