88982-82-5

Basic information

• Product Name: 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID
• Synonyms: 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID;4-BROMO-2-THIAZOLE CARBOXYLIC ACID;4-BROMO-THIAZOLE-2-CARBOXYLIC ACID;4-BROMO-1,3-THIAZOLE-2-CA...;2-Thiazolecarboxylicacid,4-broMo
• CAS NO: 88982-82-5
• Molecular Formula: C₄H₂BrNO₂S
• Molecular Weight: 208.03
• Mol File: 88982-82-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 372.5±34.0 °C(Predicted)
• Appearance: /
• Density: 2.062±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.53±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID(88982-82-5)
• EPA Substance Registry System: 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID(88982-82-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 88982-82-5(Hazardous Substances Data)

Usage

Description

4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID is a heterocyclic organic compound characterized by its molecular formula C5H3BrNO2S. It features a bromine atom, a thiazole ring, and a carboxylic acid group, making it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other biologically active molecules. Its unique structure and properties have attracted research interest for potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of biologically active molecules. Its presence in the molecular structure can enhance the pharmacological properties of the resulting drugs, making it a valuable component in drug discovery and development.
Used in Agrochemical Industry:
In the agrochemical sector, 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID serves as a crucial building block in the creation of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can improve their effectiveness in controlling pests and weeds, contributing to increased crop yields and agricultural productivity.
Used in Organic Chemistry Research:
4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID is utilized as a starting material in the synthesis of diverse organic compounds in the field of organic chemistry. Its unique structure allows for various chemical reactions, enabling the creation of a wide range of organic molecules with potential applications in different industries.
Used in Biological and Pharmacological Research:
4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID has been the subject of research for its potential biological and pharmacological properties. Scientists are exploring its interactions with biological systems and its potential to modulate specific biological pathways, which could lead to the discovery of new therapeutic agents or applications in medicine and healthcare.

InChI:InChI=1S/C4H2BrNO2S/c5-2-1-9-3(6-2)4(7)8/h1H,(H,7,8)

Upstream product

• 124-38-9 carbon dioxide 
• 1613393-51-3 (3aR,5S)-5-methyl-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1 ,2]oxazole 
• 4175-77-3 2,4-dibromo-1,3-thiazole 
• 167366-05-4 4-bromo-1,3-thiazole-2-carbaldehyde 
• 959755-96-5 ethyl 4-bromothiazole-2-carboxylate 

Downstream Products

• 912639-91-9 4-bromo-1,3-thiazole-2-carboxamide 
• 886366-96-7 4-(4-fluorophenyl)thiazole-2-carboxylic acid 
• 886367-05-1 4-(4-(trifluoromethoxy)phenyl)thiazole-2-carboxylic acid 
• 1180496-00-7 N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-bromothiazole-2-carboxamide 
• 1025468-06-7 methyl 4-bromo-1,3-thiazole-2-carboxylate 
• 141761-77-5 4-bromo-2-(trifluoromethyl)thiazole 

Relevant articles and documents

FORMAMIDE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The present invention relates to a formamide compound, a preparation method therefor and an application thereof. The structure of the compound is shown in formula (I), and the definition of each variable in the formula is as provided in the description. The compound is capable of inhibiting the activity of ASK1 kinase. The compound of the present invention may be used in the treatment/prevention of diseases associated with ASK1 kinase, such as inflammatory diseases, metabolic diseases, autoimmune diseases, cardiovascular diseases, neurodegenerative diseases, cancers and other diseases.

AMINO HETEROCYCLIC COMPOUNDS AND USES THEREOF

The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory, and autoimmune diseases and cancers.

Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists

We described here the synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as potential mGluR5 antagonists. We found that a series of thiazole derivatives 6 showed better inhibitory activity against mGluR5. Compounds 6bc and 6bj have been identified as potent antagonists (IC50 = 274 and 159 nM) showing excellent in vitro stability profile. Molecular docking study using the crystal structure of mGluR5 revealed that our compounds 6bc and 6bj fit the allosteric binding site of mavoglurant well.