88534-50-3Relevant articles and documents
New Convenient Strategy for Annulation of Pyrimidines to Thiophenes or Furans via the One-pot Multistep Cascade Reaction of 1 H -Tetrazoles with Aliphatic Amines
Pokhodylo, Nazariy T.,Shyyka, Olga Ya.,Matiychuk, Vasyl S.,Obushak, Mykola D.
, p. 399 - 403 (2016/01/15)
A versatile, convenient, efficient and high-yield synthetic method for 2-R3,R4-amino-5-R1-6-R2-thieno[2,3-d]pyrimidin-4(3H)-ones, 2-R3,R4-amino-5-R1-6-R2-thieno[3,2-d]pyrimidin-4(3H)-ones, and benzofuro[3,2-d]pyrimidin-4(3H)-ones preparation has been developed. The reaction proceeded without using solvents and included several steps. A variety of thieno[2,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives with substituents of different nature were obtained in high yields from substituted alkyl 2-(1H-tetrazol-1-yl)thiophene-3-carboxylates, 3-(1H-tetrazol-1-yl)thiophene-2-carboxylates, and 3-(1H-tetrazol-1-yl)benzofuran-2-carboxylate after their treatment with aliphatic amines.
Gallium (iii)-catalysed bromocyanation of alkynes: Regio- and stereoselective synthesis of β-bromo-α,β-unsaturated nitriles
Murai, Masahito,Hatano, Ryo,Kitabata, Sachie,Ohe, Kouichi
, p. 2375 - 2377 (2011/04/18)
Treatment of arylacetylenes and cyanogen bromide in ClCH2CH 2Cl with a catalytic amount of GaCl3 afforded (Z)-β-bromoacrylonitriles with high regio- and stereoselectivity.
Synthesis of some 2-substituted-6-phenyl- and 7-phenyl-thienopyrimidin-4(3H)-ones
Shishoo, C. J.,Pathak, U. S.,Jain, K. S.,Devani, I. T.,Chhabria, M. T.
, p. 436 - 440 (2007/10/02)
The title compounds, 7a-j and 8a-c, have been prepared through cyclocondensation of the corresponding thiophene o-aminoesters (5a and 5b) with a variety of nitriles in the presence of dry hydrogen chloride gas.
