884849-32-5

Basic information

• Product Name: 5-carboxylic acid-2-(p-methoxyphenyl)benzoxazole
• Synonyms: 5-carboxylic acid-2-(p-methoxyphenyl)benzoxazole
• CAS NO: 884849-32-5
• Molecular Weight: 269.257
• Mol File: 884849-32-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-carboxylic acid-2-(p-methoxyphenyl)benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-carboxylic acid-2-(p-methoxyphenyl)benzoxazole(884849-32-5)
• EPA Substance Registry System: 5-carboxylic acid-2-(p-methoxyphenyl)benzoxazole(884849-32-5)

Safety Data

• Hazardous Substances Data: 884849-32-5(Hazardous Substances Data)

Upstream product

• 213468-59-8 S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate 
• 1571-72-8 3-amino-4-hydroxybenzoic acid 

Relevant articles and documents

p-Toluenesulfonic acid-catalyzed metal-free formal [4?+?1] heteroannulation via N[sbnd]H/O[sbnd]H/S[sbnd]H functionalization: One-pot access to 2-aryl/hetaryl/alkyl benzazole derivatives

A concise and direct one-pot [4?+?1] synthetic strategy for the construction of 2-substituted benzazoles such as benzoxazoles and benzothiazoles has been disclosed in high yields (80–98%) by cascade coupling reaction of 2-amino(thio)phenols with β-oxodithioesters. The current approach enables N[sbnd]H/O[sbnd]H/S[sbnd]H functionalization in one-pot under solventless condition leading to diverse benzazoles without use of any external metal. A wide range of 2-amino(thio)phenols and β-oxodithioesters are compatible toward this transformation with excellent functional group tolerance. Furthermore, we preempt the wider implications of this novel strategy by demonstrating its compatibility toward versatile diversification of DNA Topoisomerase-II inhibitors.