88277-50-3

Basic information

• Product Name: 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-broMo-3a,8b-dihydro-, cis-(-)-
• Synonyms: 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-broMo-3a,8b-dihydro-, cis-(-)-;3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-bromo-3a,8b-dihydro-, (3aS,8bS)-
• CAS NO: 88277-50-3
• Molecular Formula: C₁₂H₉BrO₃
• Molecular Weight: 281.10206
• Mol File: 88277-50-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-broMo-3a,8b-dihydro-, cis-(-)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-broMo-3a,8b-dihydro-, cis-(-)-(88277-50-3)
• EPA Substance Registry System: 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-broMo-3a,8b-dihydro-, cis-(-)-(88277-50-3)

Safety Data

• Hazardous Substances Data: 88277-50-3(Hazardous Substances Data)

Usage

Description

3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-bromo-3a,8b-dihydro-, cis-(-)is a distinctive chemical compound characterized by its cyclopenta[b]benzofuran ring system, featuring a carboxylic acid group at the fifth position and a bromine atom at the seventh position. 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-bromo-3a,8b-dihydro-, cis-(-)is present in a cis-(-)isomeric form, which denotes a particular spatial orientation of its atoms. Its unique molecular structure and properties suggest potential applications in pharmaceutical or material science research.

Uses

Used in Pharmaceutical Research:
3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-bromo-3a,8b-dihydro-, cis-(-)is used as a research compound for the development of new pharmaceutical agents. Its unique structure may offer novel interactions with biological targets, potentially leading to the discovery of new drugs with specific therapeutic effects.
Used in Material Science Research:
In the field of material science, 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-bromo-3a,8b-dihydro-, cis-(-)is utilized as a building block for the synthesis of new materials with tailored properties. Its molecular structure may contribute to the creation of materials with improved performance in various applications, such as sensors, catalysts, or advanced materials for specific industries.
Used in Chemical Synthesis:
3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-bromo-3a,8b-dihydro-, cis-(-)is employed as an intermediate in the synthesis of complex organic molecules. Its unique structure can be further modified or functionalized to produce a variety of chemical compounds with diverse applications in different industries.
Used in Analytical Chemistry:
3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-bromo-3a,8b-dihydro-, cis-(-)can be used as a reference material or standard in analytical chemistry for the development and validation of analytical methods. Its unique structure and properties may be useful for testing the performance of chromatographic, spectroscopic, or other analytical techniques.
Used in Environmental Science:
3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-bromo-3a,8b-dihydro-, cis-(-)may be utilized in environmental studies to understand the behavior of similar compounds in the environment, their potential impact on ecosystems, and the development of methods for their detection and monitoring.

Upstream product

• 84598-98-1 cis-1,4-bis(2,4,6-tribromophenoxy)cyclopent-2-ene 
• 3784-04-1 potassium 2,4,6-tribromophenoxide 
• 124-38-9 carbon dioxide 
• 84599-02-0 3a,8b-cis-dihydro-3H-5,7-dibromocyclopentabenzofuran 

Downstream Products

• 79021-06-0 4-[(1R,2R,3aS,8bS)-2-Hydroxy-1-((E)-(S)-3-hydroxy-oct-1-enyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-butyric acid methyl ester 
• 132203-92-0 4-[(1R,2R,3aS,8bS)-2-Hydroxy-1-((E)-(R)-3-hydroxy-oct-1-enyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-butyric acid methyl ester 
• 79021-07-1 (+)-5,6,7-trinor-4,8-inter-m-phenylene PGI₂ 
• 94076-92-3 4-[(1R,2R,3aS,8bS)-2-Acetoxy-1-((E)-3-oxo-oct-1-enyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-butyric acid methyl ester 
• 132168-46-8 4-[(1R,2R,3aS,8bS)-2-Acetoxy-1-((E)-3-hydroxy-oct-1-enyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-butyric acid methyl ester 
• 88277-18-3 4-((4aS,4bS,9aS,10aR)-2-Methyl-4,4a,4b,9a,10,10a-hexahydro-1,3,9-trioxa-indeno[1,2-a]inden-8-yl)-butyric acid methyl ester 
• 132168-45-7 (4aS,4bS,9aS,10aR)-6-Bromo-2-methyl-4,4a,4b,9a,10,10a-hexahydro-1,3,9-trioxa-indeno[1,2-a]indene-8-carboxylic acid methyl ester 
• 88277-17-2 4-(4a,5a,10b-cis-4a,10c-trans-3-methyl-1,4a,5,5a,10b,10c-hexahydrodioxin[5,4-a]cyclopenta[b]benzofuran-7-yl)butyric acid 
• 88277-16-1 (4aS,4bS,9aS,10aR)-8-Chloromethyl-2-methyl-4,4a,4b,9a,10,10a-hexahydro-1,3,9-trioxa-indeno[1,2-a]indene 
• 88277-15-0 ((4aS,4bS,9aS,10aR)-2-Methyl-4,4a,4b,9a,10,10a-hexahydro-1,3,9-trioxa-indeno[1,2-a]inden-8-yl)-methanol 
• 274250-80-5 (E)-4-[(1S,2R,3aS,8bS)-2-(Tetrahydro-pyran-2-yloxy)-1-(tetrahydro-pyran-2-yloxymethyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-but-3-enoic acid methyl ester 
• 274250-86-1 4-[(1R,2R,3aS,8bS)-2-Acetoxy-1-((E)-(S)-3-hydroxy-4-methyl-oct-1-en-6-ynyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-butyric acid methyl ester 
• 274250-87-2 4-[(1R,2R,3aS,8bS)-2-Acetoxy-1-((E)-(R)-3-hydroxy-4-methyl-oct-1-en-6-ynyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-butyric acid methyl ester 

Relevant articles and documents

Synthesis method of beraprost sodium intermediate

The invention relates to a synthesis method of a Beraprost sodium intermediate (III). Cyclopentene and N-bromo-succinimide (NBS) carry out free radical reaction to obtain dibromocyclopentene; and dibromocyclopentene reacts with 2,4,6-tribromophenol to directly generate 3,5-bis(2,4,6-tribromophenoxyl) cyclopentene (compound I) through a one-pot method. Then through Grignard reactions, a compound (I) and a compound (II) are obtained. N-bromo-succinimide and a commercial product namely cyclopentene are taken as the raw materials to synthesize dibromocyclopentene, 170 DEG C cracking and ultralow temperature reactions (-40 to -30 DEG C) are avoided, the using of bromine is also avoided, the reaction conditions are milder, and the synthesis method is more environmentally friendly and is convenient for industrial production.

Synthesis of (+)-5,6,7-trinor-4,8-inter-m-phenylene PGI2

The titled compound, which is a stable and potent analog of prostacyclin, was synthesized from readily available 1,4-dibromocyclopentene via cyclopenta[b]benzofuran carboxylic acid 5.