878798-87-9

Basic information

• Product Name: 2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid
• Synonyms: 2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid;2,8(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-, 2-(1,1-diMethylethyl) ester;N-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid
• CAS NO: 878798-87-9
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.31566
• Mol File: 878798-87-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 432.489°C at 760 mmHg
• Flash Point: 215.362°C
• Appearance: /
• Density: 1.221g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid(878798-87-9)
• EPA Substance Registry System: 2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid(878798-87-9)

Safety Data

• Hazardous Substances Data: 878798-87-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Drug Development:
2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid is employed in drug development as a building block for the creation of novel molecules with potential medicinal properties. Its presence in natural products suggests that it may have bioactive properties that can be harnessed for the treatment of various diseases.
Used in Biological Research:
2-Boc-1,2,3,4-Tetrahydroisoquinoline-8-Carboxylic Acid is used as a research tool in the study of biological processes. Its interaction with biological systems can provide insights into the mechanisms of action of various biologically active compounds, contributing to our understanding of disease pathways and potential therapeutic targets.

InChI:InChI=1/C15H19NO4/c1-15(2,3)20-14(19)16-8-7-10-5-4-6-11(13(17)18)12(10)9-16/h4-6H,7-9H2,1-3H3,(H,17,18)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 933753-84-5 1,2,3,4-tetrahydroisoquinoline-8-carboxylic acid 

Downstream Products

• 1430847-61-2 tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-(((ls,7s)-3,5-dimethyl-7-((2,2,5-trimethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-yl)oxy)adamantan-1-yl)methyl)-5-methyl-1H-pyrazol-4-yl)picolinate 
• 1235033-32-5 5-(4-(4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenoxy)butyl)-2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylic acid 
• 1235033-39-2 5-(2-(4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenoxy)ethyl)-2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylic acid 
• 1235033-40-5 5-(2-(3-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenoxy)ethyl)-2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylic acid 
• 1235032-75-3 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylic acid 
• 1235034-73-7 methyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylate 
• 1235033-31-4 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-phenoxybutyl)thiazole-4-carboxylic acid 
• 1588535-00-5 C₃₃H₃₂N₄O₄S₂ 
• 1235035-24-1 ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-iodobutyl)thiazole-4-carboxylate 

Relevant articles and documents

AZABENZIMIDAZOLE DERIVATIVES AS PI3K BETA INHIBITORS

The present invention relates to azabenzimidazole derivatives of Formula (I) (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3Kβ inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active 10 ingredient as well as the use of said compounds as a medicament.