876918-26-2

Basic information

• Product Name: 5-bromo-2-isobutoxy benzonitirle
• Synonyms: 5-bromo-2-isobutoxy benzonitirle
• CAS NO: 876918-26-2
• Molecular Formula: C₁₁H₁₂BrNO
• Molecular Weight: 254.13
• Mol File: 876918-26-2.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-bromo-2-isobutoxy benzonitirle(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-isobutoxy benzonitirle(876918-26-2)
• EPA Substance Registry System: 5-bromo-2-isobutoxy benzonitirle(876918-26-2)

Safety Data

• Hazardous Substances Data: 876918-26-2(Hazardous Substances Data)

Usage

General Description

5-bromo-2-isobutoxy benzonitrile is a chemical compound that consists of a benzene ring attached to a nitrile group, with a bromine atom and an isobutoxy group as substituents on the benzene ring. It is commonly used as a building block in organic synthesis, particularly in the pharmaceutical and agrochemical industries. 5-bromo-2-isobutoxy benzonitirle is known for its versatile reactivity, making it valuable in the creation of various biologically active molecules. Additionally, its bromine atom provides a site for further functionalization, allowing for the creation of more complex chemical structures. Overall, 5-bromo-2-isobutoxy benzonitrile is a useful and important compound in the field of organic chemistry.

Upstream product

• 2042-37-7 o-cyanobromobenzene 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 106-41-2 4-bromo-phenol 
• 4885-02-3 Dichloromethyl methyl ether 
• 30752-23-9 4-bromophenyl iso-butyl ether 
• 184970-28-3 4-bromo-2-(bromomethyl)-1-methoxybenzene 
• 14804-31-0 2-methyl-4-bromoanisole 
• 144649-99-0 5-bromo-2-methoxybenzonitrile 
• 513-38-2 Isobutyl iodide 
• 78-83-1 2-methyl-propan-1-ol 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 222315-01-7 5-bromo-2-isobutoxybenzaldehyde 
• 78-77-3 Isobutyl bromide 

Downstream Products

• 144060-53-7 febuxostat 
• 160844-75-7 2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester 
• 206884-89-1 ethyl 1-(3'-cyano-4'-isobutoxyphenyl)-pyrazol-4-carboxylate 
• 1139901-87-3 5-iodo-2-isobutoxy-benzonitrile 
• 1562039-91-1 2-iso-butoxy-5-formylbenzonitrile 
• 1574394-62-9 C₁₇H₁₇N₅O₂ 
• 1574394-61-8 5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile 
• 1574394-60-7 2-amino-4-(3-cyano-4-isobutoxyphenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 
• 1415309-89-5 5-(2-amino-6-oxo-1,6-dihydropyrimidin-4-yl)-2-isobutoxybenzonitrile 
• 1352943-58-8 2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 876918-32-0 (3-cyano-4-isobutoxyphenyl)boronic acid 
• 1139901-88-4 tert-butyl 2-(3’-cyano-4’-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 
• 1240593-43-4 C₂₂H₂₄N₂O₂ 
• 1240593-44-5 C₁₈H₂₄N₂O₄S₂ 

Relevant articles and documents

Synthesis and bioevaluation of 1-phenylimidazole-4-carboxylic acid derivatives as novel xanthine oxidoreductase inhibitors

As part of a continuing study, we designed and synthesized four series of 1-phenylimidazole-4-carboxylic acid derivatives as xanthine oxidoreductase (XOR) inhibitors, evaluated their in vitro inhibitory potencies against XOR and hypouricemic effects in mi

A method for preparing [...]

The invention discloses a method for preparing [...], relates to a pharmaceutical technical field of chemical synthesis, comprising the following steps: to adjacent bromobenzylcyanide as raw materials with the isobutyl alcohol in the etherification reaction under alkaline conditions, to obtain 2 - [...]; to hydrogen peroxide/hydrogen bromic acid system for the oxidation of bromide, 2 - [...] oxidation bromination reaction, to obtain 2 - isobuoxy - 5 - bromobenzylcyanide; the 2 - isobuoxy - 5 - bromobenzylcyanide with 2 - boric acid - 4 - methyl - 1, 3 - thiazole - 5 - carboxylic acid ethyl ester in Suziki coupling reaction, to obtain 2 - [3 - cyano - 4 - isobuoxy phenyl] - 4 - methyl thiazole - 5 - carboxylic acid ethyl ester; the 2 - [3 - cyano - 4 - isobuoxy phenyl] - 4 - methyl thiazole - 5 - carboxylic acid ethyl ester under basic condition to obtain [...]. The invention routes and novel and short synthetic route, requires only four-step reaction can be to obtain the target product, used in the preparation raw materials are cheap and easy to obtain, environmental protection, mild reaction conditions, the operation is convenient and controllable, the prepared [...] high purity, high yield.

Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors

A diverse library of 1-phenyl-pyrazole-4-carboxylic acid derivatives were synthesized and evaluated for their inhibitory potency against xanthine oxidoreductase (XOR) in vitro and vivo, and the structure-activity relationship (SAR) analyses were also pres