876861-29-9 Usage
Description
5-Bromo-3-fluorobenzene-1,2-diol is an organic compound characterized by the presence of a bromine atom at the 5th position and a fluorine atom at the 3rd position on a benzene ring, with two hydroxyl groups attached to the 1st and 2nd carbons. This unique molecular structure endows it with specific chemical properties that make it a valuable intermediate in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Synthesis:
5-Bromo-3-fluorobenzene-1,2-diol is used as a reagent in the synthesis of N-(hydroxy(pyrrolidinyl)propanyl)pyrrolidinecarboxamide derivatives. These derivatives act as glucosylceramide synthase inhibitors, which are important in the treatment of lysosomal storage disorders such as Gaucher disease. The inhibition of glucosylceramide synthase helps to reduce the accumulation of glucosylceramide in cells, thereby alleviating the symptoms associated with these disorders.
Additionally, 5-Bromo-3-fluorobenzene-1,2-diol is utilized in the preparation of 5,5-disubstituted-2-iminopyrrolidine derivatives. These compounds serve as thrombin receptor antagonists, playing a crucial role in the regulation of blood clotting. Thrombin receptor antagonists can be employed in the development of antithrombotic drugs, which are essential for the prevention and treatment of various cardiovascular conditions, including deep vein thrombosis, pulmonary embolism, and stroke.
Check Digit Verification of cas no
The CAS Registry Mumber 876861-29-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,6,8,6 and 1 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 876861-29:
(8*8)+(7*7)+(6*6)+(5*8)+(4*6)+(3*1)+(2*2)+(1*9)=229
229 % 10 = 9
So 876861-29-9 is a valid CAS Registry Number.
876861-29-9Relevant articles and documents
PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
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, (2017/11/06)
The invention provides substituted pyrazolo[1,5-a]pyrimidinyl carboxamide and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrazolo[1,5-a]pyrimidinyl carboxamide compounds described herein include 2-heterocyclyl-4-alkyl-pyrazolo[1,5-a]pyrirnidine-3-carboxarnide compounds and variants thereof.
GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES
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, (2015/04/15)
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
METHOD FOR PRODUCING DIBROMOFLUOROBENZENE DERIVATIVE
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Page/Page column 11, (2008/06/13)
Methods of the present invention for producing dibromofluorobenzene derivatives (compounds II) comprise Step 1, in which compounds (I) having the following general formula (I): epImage id=""ia01"" he=""33"" wi=""128"" file=""imga0001.tif"" img-content=""