876380-66-4 Usage
Description
Adenosine, 2'-deoxy-8-[(2-hydroxyethyl)thio]is a chemical compound that serves as an intermediate in the synthesis of 8-Oxo-2'-deoxyadenosine (O850225). Adenosine, 2'-deoxy-8-[(2-hydroxyethyl)thio]plays a significant role in the stabilization of human telomeric G-quadruplex DNA, which is crucial for understanding the structure and function of DNA.
Uses
Used in Pharmaceutical Industry:
Adenosine, 2'-deoxy-8-[(2-hydroxyethyl)thio]is used as an intermediate in the synthesis of 8-Oxo-2'-deoxyadenosine for its potential applications in the development of drugs targeting human telomeric G-quadruplex DNA. This stabilization can have implications in the treatment of diseases associated with DNA damage and telomere dysfunction.
Used in Research and Development:
Adenosine, 2'-deoxy-8-[(2-hydroxyethyl)thio]is used as a research compound to study the structure and function of human telomeric G-quadruplex DNA. Understanding the interactions and stabilization mechanisms of this compound can contribute to the advancement of DNA-related research and the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 876380-66-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,6,3,8 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 876380-66:
(8*8)+(7*7)+(6*6)+(5*3)+(4*8)+(3*0)+(2*6)+(1*6)=214
214 % 10 = 4
So 876380-66-4 is a valid CAS Registry Number.
876380-66-4Relevant articles and documents
A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water
Chatgilialoglu, Chryssostomos,Navacchia, Maria Luisa,Postigo, Al
, p. 711 - 714 (2006)
Reaction of 2-mercaptoethanol with 8-bromo-2′-deoxyadenosine and 8-bromo-adenosine in aqueous solution and in the presence of triethylamine gave the 8-oxo-adenine derivatives in very good yields. Some mechanistic details are reported.
