87344-06-7

Basic information

• Product Name: Amtolmetin guacil
• Synonyms: 2-(2-Methoxyphenyl)-2-(N-{1-Methyl-5-[(4-Methylphenyl)carbonyl]-1H-pyrrol-2-yl}acetaMido)acetate;ArtroMed;Eufans;AMtolMethin Guacil;AMtolMetin Guacyl;N-[2-[1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl]acetyl]glycine 2-Methoxyphenyl Ester;2-Methoxyphenyl 2-(2-(1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl)acetaMido)acetate;2-methoxyphenyl1-methyl-5-p-methylbenzoylpyrrole-2-acetoamidoacetate
• CAS NO: 87344-06-7
• Molecular Formula: C24H24N2O5
• Molecular Weight: 420.46
• Product Categories: Pharmaceuticals;Aromatics;Heterocycles;Intermediates & Fine Chemicals
• Mol File: 87344-06-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 117-120°
• Boiling Point: 663.3 °C at 760 mmHg
• Flash Point: 354.9 °C
• Appearance: white needle-shaped crystal
• Density: 1.19 g/cm³
• Vapor Pressure: 1.84E-17mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Amtolmetin guacil(CAS DataBase Reference)
• NIST Chemistry Reference: Amtolmetin guacil(87344-06-7)
• EPA Substance Registry System: Amtolmetin guacil(87344-06-7)

Safety Data

• Hazardous Substances Data: 87344-06-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Amtolmetin guacil is used as an analgesic and anti-inflammatory agent for the treatment of rheumatoid arthritis. It is effective in reducing pain and inflammation associated with the condition, improving the quality of life for patients.
Used in Orthopedic Industry:
Amtolmetin guacil is used for the treatment of osteoarthritis, a degenerative joint disease that affects millions of people worldwide. It helps to alleviate the pain and inflammation associated with this condition, allowing patients to maintain an active lifestyle.
Used in Post-operative Pain Management:
Amtolmetin guacil is used as a post-operative pain management agent, providing effective pain relief following surgical procedures. Its rapid and improved analgesic action makes it a valuable option for patients recovering from surgery.
Used in Drug Development Research:
Amtolmetin guacil serves as a reference compound in drug development research, particularly in the development of new NSAIDs and other anti-inflammatory agents. Its unique properties, such as lower ulcerogenic action and excellent gastric tolerability, make it a valuable model for researchers to study and improve upon in the quest for safer and more effective medications.

Originator

Sigma Tau (Italy)

InChI:InChI=1/C24H24N2O5/c1-16-8-10-17(11-9-16)24(29)19-13-12-18(26(19)2)14-22(27)25-15-23(28)31-21-7-5-4-6-20(21)30-3/h4-13H,14-15H2,1-3H3,(H,25,27)

Upstream product

• 90-05-1 2-methoxy-phenol 
• 87344-05-6 Tolmetin glycine amide 
• 26171-23-3 1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid 
• 33369-52-7 methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate 
• 51856-79-2 N-methyl-2-(methoxycarbonylmethyl)pyrrole 
• 75368-99-9 amino acetic acid guacil ester hydrochloride 
• 21898-43-1 2-(1-methyl-1H-pyrrol-2-yl)-2-oxoacetic acid 
• 93962-13-1 C₁₈H₂₀N₂O₄ 
• 1207070-74-3 tert-butyloxycarbonylamino acetic acid guacil ester 
• 21898-59-9 1-methylpyrrole-2-acetic acid 
• 96-54-8 N-Methylpyrrole 

Relevant articles and documents

Synthesis and process optimization of amtolmetin: An antiinflammatory agent

Efforts toward the synthesis and process optimization of amtolmetin guacil 1 are described. High-yielding electrophilic substitution followed by Wolf-Kishner reduction are the key features in the novel synthesis of tolmetin 2 which is an advanced intermediate of 1.