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2,6-Dichloro-3,5-dimethoxyaniline, also known as dichloroaniline, is an organic compound with the molecular formula C8H9Cl2NO2. It belongs to the aniline family and is characterized by its pale yellow to brownish solid appearance. This chemical is primarily utilized as an intermediate in the synthesis of various products, including dyes, pigments, pharmaceuticals, and agricultural chemicals. Due to its moderately toxic nature, it can cause irritation to the skin, eyes, and respiratory system, necessitating careful handling and the implementation of proper safety measures.

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  • 872509-56-3 Structure
  • Basic information

    1. Product Name: 2,6-Dichloro-3,5-dimethoxyaniline
    2. Synonyms: 2,6-Dichloro-3,5-dimethoxyaniline;2,6-Dichloro-3,5-dimethoxybenzenamine;Benzenamine, 2,6-dichloro-3,5-dimethoxy-;2,6-Dichloro-3,5-dimethoxy-phenylamine
    3. CAS NO:872509-56-3
    4. Molecular Formula: C8H9Cl2NO2
    5. Molecular Weight: 222.06856
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 872509-56-3.mol
    9. Article Data: 12
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 320℃
    3. Flash Point: 147℃
    4. Appearance: /
    5. Density: 1.357
    6. Refractive Index: N/A
    7. Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
    8. Solubility: N/A
    9. PKA: -0.13±0.10(Predicted)
    10. CAS DataBase Reference: 2,6-Dichloro-3,5-dimethoxyaniline(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,6-Dichloro-3,5-dimethoxyaniline(872509-56-3)
    12. EPA Substance Registry System: 2,6-Dichloro-3,5-dimethoxyaniline(872509-56-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 872509-56-3(Hazardous Substances Data)

872509-56-3 Usage

Uses

Used in Dye and Pigment Production:
2,6-Dichloro-3,5-dimethoxyaniline is used as a chemical intermediate for the production of dyes and pigments. Its unique chemical structure allows for the creation of a wide range of colorants used in various industries.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2,6-Dichloro-3,5-dimethoxyaniline serves as a key intermediate in the synthesis of certain drugs. Its reactivity and functional groups make it a valuable component in the development of new medicinal compounds.
Used in Agricultural Chemicals:
2,6-Dichloro-3,5-dimethoxyaniline is also utilized as an intermediate in the production of agricultural chemicals. Its role in the synthesis of various agrochemicals contributes to its importance in this sector.
Safety Precautions:
Given its moderately toxic nature, 2,6-Dichloro-3,5-dimethoxyaniline requires careful handling to prevent irritation and potential harm to individuals and the environment. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, are essential when working with this chemical compound.

Check Digit Verification of cas no

The CAS Registry Mumber 872509-56-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,2,5,0 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 872509-56:
(8*8)+(7*7)+(6*2)+(5*5)+(4*0)+(3*9)+(2*5)+(1*6)=193
193 % 10 = 3
So 872509-56-3 is a valid CAS Registry Number.

872509-56-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Benzenamine, 2,?6-?dichloro-?3,?5-?dimethoxy-

1.2 Other means of identification

Product number -
Other names 2,6-Dichloro-3,5-dimethoxyaniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:872509-56-3 SDS

872509-56-3Downstream Products

872509-56-3Relevant articles and documents

Heterocyclic compounds as FGFR4 inhibitors

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Paragraph 0127; 0146-0148, (2021/02/10)

The present invention provides heterocyclic compounds as selective inhibitors of fibroblast growth factor receptor 4 (FGFR4), pharmaceutical compositions containing the compounds, methods of preparingthe compounds, and methods of treating cell proliferative diseases, such as cancer, using the compounds of the invention.

Pyrido[2,3-b]pyrazine-3(4H)-ketone derivative and application thereof

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Paragraph 0019-0020; 0038; 0040, (2021/03/13)

The invention provides a pyrido[2,3-b]pyrazine-3(4H)-ketone derivative and application thereof. The structural general formula of the pyrido[2,3-b]pyrazine-3(4H)-ketone derivative is a formula V, andthe pyrido[2,3-b]pyrazine-3(4H)-ketone derivative comprises pharmaceutically acceptable salt, solvate, hydrate or crystal form thereof. The compound provided by the invention is an active ligand of afibroblast growth factor receptor (FGFR), and research shows that the compound shown in the structure V has good anti-proliferative activity on KATO III gastric cancer cells (FGFR2 amplification) andHuh-7 liver cancer cells (FGFR4 overexpression), and is applied to preparation of drugs for treating tumor-related diseases caused by FGFR abnormal activation as an FGFR inhibitor. The structural general formula V is shown in the description.

Preparation method of kinase inhibitor intermediate

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, (2021/02/10)

The invention relates to a synthetic method of a kinase inhibitor intermediate, namely 2, 6-dichloro-3, 5-methoxyaniline (I), belongs to the field of organic synthesis, and has the advantages of safeand stable route, convenience in operation, easiness in

HETEROARYLAMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

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Paragraph 0098; 0099, (2016/06/21)

A heteroarylamine compound includes protein kinase inhibition activity, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for preventing and treating a disease caused by abnormal cell growth, which contains the compound as an act

FGFR4 INHIBITORS

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Page/Page column 36, (2016/10/31)

Methods, compounds, pharmaceutical compositions, and methods of preparing medicaments for treating hepatocellular carcinoma having an altered FGFR4 and/or FGF19 status.

FGFR4 INHIBITORS

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Page/Page column 33, (2016/10/31)

We provide FGFR inhibitors, their salts, methods of manufacture, and methods of use.

BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS

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Page/Page column 80, (2016/09/15)

The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in the treatment of FGFR4-associated diseases such as cancer.

PYRIMIDINE FGFR4 INHIBITORS

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Page/Page column 35, (2015/05/05)

Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl- piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase

Guagnano, Vito,Furet, Pascal,Spanka, Carsten,Bordas, Vincent,Le Douget, Micka?l,Stamm, Christelle,Brueggen, Josef,Jensen, Michael R.,Schnell, Christian,Schmid, Herbert,Wartmann, Markus,Berghausen, Joerg,Drueckes, Peter,Zimmerlin, Alfred,Bussiere, Dirksen,Murray, Jeremy,Graus Porta, Diana

experimental part, p. 7066 - 7083 (2011/12/04)

A novel series of N-aryl-N′-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the fibroblast growth factor receptor tyrosine kinases 1, 2, and 3 by rationally designing the substitution pattern of the aryl ring. On the b

[4,5']BIPYRIMIDINYL-6,4'-DIAMINE DERIVATIVES AS PROTEIN KINASE INHBITORS

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Page/Page column 36, 37, 64, (2008/06/13)

The invention provides a novel class of compounds of the Formula (I): in which the symbols have the meanings given in the description and claims, to pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prev

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