866319-00-8

Basic information

• Product Name: 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE;5-FLUORO-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-;5-Fluoro-7-azaindole (5-Fluoro-1H-pyrrolo[2,3-b]pyridine);EOS-60587;5-Fluoro-1H-pyrrolo[2,3-b]pyridin
• CAS NO: 866319-00-8
• Molecular Formula: C₇H₅FN₂
• Molecular Weight: 136.13
• Product Categories: Heterocycles series;CHIRAL CHEMICALS;Fluorine series
• Mol File: 866319-00-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 112-113°C
• Appearance: /
• Density: 1.35
• Refractive Index: 1.658
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.04±0.40(Predicted)
• CAS DataBase Reference: 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE(866319-00-8)
• EPA Substance Registry System: 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE(866319-00-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 866319-00-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H5FN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10)

Upstream product

• 936344-74-0 3-ethynyl-5-fluoro-pyridin-2-ylamine 
• 868387-37-5 5‐fluoro-1-triisopropylsilylpyrrolo[2,3‐b]pyridine 
• 866319-01-9 5-fluoro-3-(2-trimethylsilylethynyl)pyridine-2-amine 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 869557-43-7 3-bromo-5-fluoropyridin-2-amine 
• 75-07-0 acetaldehyde 
• 21717-96-4 2-amino-5-fluoropyridine 
• 823218-51-5 5-fluoro-3-iodo-pyridin-2-amine 
• 14618-78-1 4,4-dimethoxybutanenitrile 

Downstream Products

• 1171920-17-4 5-fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 1243165-09-4 5-fluoro-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine 
• 1190321-96-0 6-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine 
• 1428969-87-2 1-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-((3-methoxyphenyl)amino)-2-phenylethanone 
• 1428969-93-0 2-((3,5-dimethoxyphenyl)amino)-1-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-phenylethanone 
• 1417421-99-8 3-bromo-5-fluoro-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1259279-57-6 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 900514-10-5 5-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine 
• 1222533-84-7 3-BPin-5-fluoro-7-azaindole 
• 1259279-56-5 5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine 
• 1259279-58-7 5-fluoro-3-(5-fluoro-4-methylsulfinyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

ANTI-INFLUENZA VIRUS PYRIMIDINE DERIVATIVE

The present invention discloses a class of anti-influenza virus compounds, and the use thereof in the preparation of a drug for treating diseases associated with influenza viruses. In particular, the present invention discloses a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

INHIBITORS OF CYCLIN DEPENDNT KINASE 7 (CDK7)

The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION

A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base