865713-88-8

Basic information

• Product Name: 4-chloro-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
• Synonyms: 4-chloro-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
• CAS NO: 865713-88-8
• Molecular Weight: 342.828
• Mol File: 865713-88-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide(865713-88-8)
• EPA Substance Registry System: 4-chloro-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide(865713-88-8)

Safety Data

• Hazardous Substances Data: 865713-88-8(Hazardous Substances Data)

Upstream product

• 102-48-7 3,4-Dimethylbenzylamin 
• 52833-03-1 4-chloro-1-ethyl-1H-pyrazolo<3,4-b>pyridine-5-carbonyl chloride 

Downstream Products

• 865713-86-6 4-([1-(aminocarbonyl)-4-piperidinyl]amino)-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 

Relevant articles and documents

PYRAZOLO[3,4-B]PYRIDINE COMPOUND, AND ITS USE AS A PDE4 INHIBITOR

The invention provides 4-{[1-(aminocarbonyl)-4-piperidinyl]amino}-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carb oxamide, which is the compound of formula (I), or a salt thereof. The invention also provides the use of said compound or a pharmaceutically acceptable salt thereof as an inhibitor of phosphodiesterase type IV (PDE4), for example in the treatment and/or prophylaxis of an inflammatory and/or allergic disease, cognitive impairment or depression in a mammal. In particular, the invention provides the use of the compound or pharmaceutically acceptable salt in the treatment and/or prophylaxis of atopic dermatitis in a mammal, for example by external topical administration to the mammal such as a human. Pharmaceutical compositions containing said compound or salt, in particular suitable for external topical administration, are also provided.