865311-47-3 Usage
Description
CX-3543, also known as Quarfloxin, is a small molecule that specifically targets and binds to G-quadruplex DNA structures, inhibiting ribosomal RNA synthesis and disrupting nucleolar function. This action leads to the activation of apoptotic pathways and induces cell death in cancer cells, making it a promising anti-tumor agent.
Used in Pharmaceutical Industry:
CX-3543 is used as an anti-tumor agent for its ability to inhibit ribosomal RNA synthesis and disrupt nucleolar function, leading to the activation of apoptotic pathways and cell death in cancer cells, particularly in solid tumors such as small cell lung cancer and neuroendocrine tumors.
Used in Combination Therapy:
CX-3543 is used as a synergistic agent in combination therapy for its demonstrated effects with other anti-cancer agents, enhancing the overall therapeutic efficacy in the treatment of various cancer types.
Used in Preclinical Studies and Clinical Trials:
CX-3543 is used as a subject of investigation in preclinical studies and early phase clinical trials to evaluate its anti-tumor activity and potential as a therapeutic agent for cancer treatment. Further research and clinical trials are necessary to fully understand its capabilities and optimize its use in cancer therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 865311-47-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,3,1 and 1 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 865311-47:
(8*8)+(7*6)+(6*5)+(5*3)+(4*1)+(3*1)+(2*4)+(1*7)=173
173 % 10 = 3
So 865311-47-3 is a valid CAS Registry Number.
865311-47-3Relevant articles and documents
Facile and efficient generation of quinolone amides from esters using aluminum chloride
Schwaebe, Michael K.,Ryckman, David M.,Nagasawa, Johnny Y.,Pierre, Fabrice,Vialettes, Anne,Haddach, Mustapha
scheme or table, p. 1096 - 1100 (2011/03/22)
Quinolone esters are readily converted into the corresponding amides using aluminum chloride at room temperature in excellent yields and purities. The method is both general and scalable to multi-kilogram quantities.
