86101-48-6

Basic information

• Product Name: 2,2-dimethyl-4-Pentynoic acid
• Synonyms: 2,2-dimethyl-4-Pentynoic acid
• CAS NO: 86101-48-6
• Molecular Weight: 126.155
• Mol File: 86101-48-6.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-4-Pentynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-4-Pentynoic acid(86101-48-6)
• EPA Substance Registry System: 2,2-dimethyl-4-Pentynoic acid(86101-48-6)

Safety Data

• Hazardous Substances Data: 86101-48-6(Hazardous Substances Data)

Usage

General Description

2,2-dimethyl-4-Pentynoic acid, also known as 2,2-dimethyl-4-pentyne-3-ol, is a chemical compound with the molecular formula C7H12O2. It is a colorless oil with a pungent odor and is used in the production of pharmaceuticals and organic intermediates. It is also known for its ability to act as a corrosion inhibitor in lubricating oils and as a chemical intermediate in the synthesis of agrochemicals. Additionally, 2,2-dimethyl-4-Pentynoic acid is used in the production of coatings, adhesives, and sealants. It is important to handle this chemical with care as it can be hazardous if not properly managed.

Upstream product

• 86101-49-7 Methyl 2,2-Dimethylpent-4-ynoate 
• 75-98-9 Trimethylacetic acid 
• 107540-02-3 ethyl 2,2-dimethyl-4-pentynoate 
• 106-96-7 propargyl bromide 
• 79-31-2 isobutyric Acid 

Downstream Products

• 167390-48-9 N-benzyl-2,2-dimethyl-4-pentynamide 
• 1044507-20-1 2,2-dimethyl-5-(4-methylphenyl)pent-4-ynoic acid 
• 470-49-5 2,2-dimethyl-4-oxo-pentanoic acid 
• 1397290-00-4 2,2-dimethylpent-3-ynal 
• 1612869-08-5 (1S,2S)-1-((S)-6-allyl-6-methylcyclohex-1-enyl)-2-hydroxy-5-methyl-2-(2-methylpent-3-yn-2-yl)hex-4-enyl benzoate 
• 1612869-07-4 (1R,2R)-1-((S)-6-allyl-6-methylcyclohex-1-enyl)-2-hydroxy-5-methyl-2-(2-methylpent-3-yn-2-yl)hex-4-enyl benzoate 
• 1612868-99-1 (4S,5S)-5-((S)-6-allyl-6-methylcyclohex-1-enyl)-4-(3-methylbut-2-enyl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one 
• 1612868-98-0 (4R,5R)-5-((S)-6-allyl-6-methylcyclohex-1-enyl)-4-(3-methylbut-2-enyl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one 
• 1612868-97-9 (4S,5S)-5-((S)-6-(3-hydroxypropyl)-6-methylcyclohex-1-enyl)-4-(3-methylbut-2-enyl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one 
• 1612868-96-8 (4R,5R)-5-((S)-6-(3-hydroxypropyl)-6-methylcyclohex-1-enyl)-4-(3-methylbut-2-enyl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one 
• 1612868-95-7 (4S,5S)-5-((S)-6-methyl-6-(3-(trityloxy)propyl)cyclohex-1-enyl)-4-(3-methylbut-2-enyl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one 
• 1612868-94-6 (4R,5R)-5-((S)-6-methyl-6-(3-(trityloxy)propyl)cyclohex-1-enyl)-4-(3-methylbut-2-enyl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one 

Relevant articles and documents

Chiral Deuterium Labeling: New Method for Determination of Rotational Propensities

Determination of internal rotational propensities in thermal rearrangements of cyclic compounds has, in the past, involved the use of optical activity as a tracer and has required usually arduous correlation of configurations between the educt and products by chemical means.Replacement of this method by introduction of a chiral, diastereomeric deuterium hydrogen methylene group permits configurational relations to be established by NMR - either 2H NMR or 1H NMR alone or with LIS enhancement.As a first application of the new method, the relative rotational propensity, RA, of the cyano and isobutenyl groups in 1-cyano-2-isobutenyl-2,3-dideuteriocyclopropane has been determined to be 3.9 +/- 0.5.

Copper-Catalyzed Modular Access to N-Fused Polycyclic Indoles and 5-Aroyl-pyrrol-2-ones via Intramolecular N—H/C—H Annulation with Alkynes: Scope and Mechanism Probes

Copper-catalyzed intramolecular N—H/C—H annulation with alkynes has been developed. A variety of densely functionalized heterocycles, such as pyrrolo[1,2-a]indoles, indolo[1,2-c]quinazolin-2-ones, oxazolo[3,4-a]indoles, and imidazo[1,5-a]indoles, were synthesized in an atom- and step-economical manner, owing to the high modularized feature of aniline moiety, the linker moiety, as well as the alkyne moiety. By simply changing the oxidant from di-tert-butyl peroxide (DTBP) to 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), the reaction could readily be transformed to the aminooxygenation pathway, which grabs one oxygen atom from the TEMPO to generate 5-aroyl-pyrrol-2-ones. Mechanistic experiments indicate that vinyl radical is involved in this reaction and an amidyl-radical-initiated radical cascade might be responsible for this transformation.

Single-Molecule Observation of the Intermediates in a Catalytic Cycle

The development of catalysts benefits from knowledge of the intermediate steps that accelerate the transformations of substrates into products. However, key transient species are often hidden in ensemble measurements. Here, we show that a protein nanoreac