858643-92-2

Basic information

• Product Name: 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester;1-Boc-3-acetylpiperidine;tert-butyl 3-acetylpiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-acetyl-, 1,1-diMethylethyl ester;3-Acetyl-1-piperidinecarboxylic acid tert-butyl ester
• CAS NO: 858643-92-2
• Molecular Formula: C₁₂H₂₁NO₃
• Molecular Weight: 227.30004
• EINECS: 200-589-5
• Mol File: 858643-92-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 312.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.052
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.40±0.40(Predicted)
• CAS DataBase Reference: 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester(858643-92-2)
• EPA Substance Registry System: 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester(858643-92-2)

Safety Data

• Hazardous Substances Data: 858643-92-2(Hazardous Substances Data)

Usage

Description

3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester is a versatile chemical compound that serves as a key intermediate in the synthesis of pharmaceuticals and organic molecules. It is a derivative of piperidine, featuring a six-membered heterocyclic ring with nitrogen, and is equipped with an acetyl group and a tert-butyl ester functional group. 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester's unique structure and reactivity make it an indispensable building block in the creation of complex organic molecules, playing a pivotal role in the field of synthetic organic chemistry and drug discovery.

Uses

Used in Pharmaceutical Synthesis:
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester is used as a key intermediate for the production of various drugs. Its presence in the synthesis process is crucial for the development of new pharmaceuticals, as it can be modified and combined with other compounds to create a wide range of medicinal agents.
Used in Organic Chemistry Research:
In the realm of organic chemistry, 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester is utilized as a building block for the creation of complex organic molecules. Its unique structure allows researchers to explore new reactions and pathways, contributing to the advancement of organic chemistry and the discovery of novel compounds with potential applications in various industries.
Used in Drug Discovery:
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester is employed as a valuable tool in drug discovery. Its reactivity and structural features enable the design and synthesis of new drug candidates, accelerating the process of identifying potential therapeutic agents and contributing to the development of innovative treatments for various diseases and conditions.

Upstream product

• 75-16-1 methylmagnesium bromide 
• 189442-78-2 (±)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 
• 676-58-4 methylmagnesium chloride 
• 148672-74-6 ethyl N-(t-butyloxycarbonyl)nipecotate 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 88495-54-9 (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid 
• 1008562-93-3 (S)-3-(methoxy-methyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1235439-55-0 3-(1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1188264-16-5 tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate 
• 1374353-21-5 tert-butyl 3-(1-(3-(pyridin-4-yl)-1-trityl-1H-indazol-5-yl)-1H-pyrazol-3-yl)piperidine-1-carboxylate 
• 1374351-14-0 5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole 
• 377780-25-1 3-(1-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to pyrazolopyrimidine derivatives having dual pharmacological activity towards both the α2δ subunit of the voltage-gated calcium channel and the sigma-1 (σ1) receptor, to processes of preparation of such compounds,

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS

The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.

PIPERIDINE AMIDES AS MODULATORS OF THE GHRELIN RECEPTOR

Compounds of formula (I) or pharmaceutically acceptable salts thereof, are useful for the treatment of diabetes and obesity.