858354-78-6

Basic information

• Product Name: (S)-BoroAla-(-)-Pinanediol-HCl
• Synonyms: (S)-BoroAla-(-)-Pinanediol-HCl;(S)-BoroAla-(-)-Pinanediol-HC
• CAS NO: 858354-78-6
• Molecular Formula: C12H23BClNO2
• Molecular Weight: 259.58
• Mol File: 858354-78-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-BoroAla-(-)-Pinanediol-HCl(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-BoroAla-(-)-Pinanediol-HCl(858354-78-6)
• EPA Substance Registry System: (S)-BoroAla-(-)-Pinanediol-HCl(858354-78-6)

Safety Data

• Hazardous Substances Data: 858354-78-6(Hazardous Substances Data)

Usage

General Description

(S)-BoroAla-(-)-Pinanediol-HCl is a chemical compound that contains two main components: BoroAla and (-)-Pinanediol, both of which are the salt forms of organic acids. BoroAla is a boronate ester derivative of alanine, a non-essential amino acid that is important for the synthesis of proteins. (-)-Pinanediol, on the other hand, is a chiral compound that is often used as a chiral auxiliary in organic synthesis. The HCl in the compound's name indicates that it is in the hydrochloride salt form, which is commonly used to improve the solubility and stability of the compound in aqueous solutions. This chemical is often utilized in organic chemistry as a chiral catalyst or as a building block for the synthesis of complex organic molecules.

Upstream product

• 132562-14-2 C₁₂H₂₀BClO₂ 
• 132562-17-5 C₁₈H₃₈BNO₂Si₂ 
• 1313706-65-8 C₁₈H₃₈BNO₂Si₂ 
• 53404-49-2 2,3-trans-pinanediol 
• 497165-15-8 D-1-(aminoethyl)boronic acid pinanediol ester 
• 132562-10-8 methylboronic acid pinanediol ester 
• 85167-12-0 (+)-pinanediol (1S)-1-chloro-1-ethaneboronate 
• 87247-50-5 C₇H₇BO₂(CH₃)3(CHClCH₃) 
• 84110-38-3 (1S,2S,3R,5S)-2α,3α-pinanediol methylboronic ester 
• 7785-70-8 (+)-α-pinene 
• 18680-27-8 pinanediol 

Downstream Products

• 1451205-23-4 C₄₂H₆₁BClN₇O₇ 

Relevant articles and documents

Synthesis and antimicrobial activity of α-aminoboronic-containing peptidomimetics

A library of 175 dipeptidomimetics and tripeptidomimetics containing an α-amino boronic acid or boronate has been synthesized, and the activity toward Mycobacterium tuberculosis, Candida albicans, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa has been screened. Although there is no clear structure-activity relationship, several compounds exhibit promising activity against different pathogens. Copyright

Structure guided development of potent reversibly binding penicillin binding protein inhibitors

Following from the evaluation of different types of electrophiles, combined modeling and crystallographic analyses are used to generate potent boronic acid based inhibitors of a penicillin binding protein. The results suggest that a structurally informed approach to penicillin binding protein inhibition will be useful for the development of both improved reversibly binding inhibitors, including boronic acids, and acylating inhibitors, such as β-lactams.

Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases

Seven PNA-encoded combinatorial libraries targeting proteases and phosphatases with covalent reversible and irreversible mechanism-based inhibitors were prepared. The libraries were synthesized using modified PNA monomers, which dramatically increase the water solubility of the libraries in biologically relevant buffers. The libraries were shown to selectively inhibit targeted enzymes.