85430-60-0

Basic information

• Product Name: NSC 206120
• Synonyms: 3-Nitro-2-oxazolidinone;NSC 206120
• CAS NO: 85430-60-0
• Molecular Formula: C₃H₄N₂O₄
• Molecular Weight: 132.07486
• Product Categories: Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 85430-60-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 222.3°Cat760mmHg
• Flash Point: 88.3°C
• Appearance: /
• Density: 1.6g/cm³
• Vapor Pressure: 0.102mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: Refrigerator
• Solubility: Acetone, Chloroform, Dichloromethane, Methanol
• CAS DataBase Reference: NSC 206120(CAS DataBase Reference)
• NIST Chemistry Reference: NSC 206120(85430-60-0)
• EPA Substance Registry System: NSC 206120(85430-60-0)

Safety Data

• Hazardous Substances Data: 85430-60-0(Hazardous Substances Data)

Usage

Description

NSC 206120, also known as 3-Nitro-2-oxazolidinone, is a chemical compound that functions as an inhibitor of aldehyde dehydrogenase (ALDH). It is particularly useful in research settings where the inhibition of ALDH is required to study its role in various biological processes.

Uses

Used in Research Applications:
NSC 206120 is used as an inhibitor for aldehyde dehydrogenase (ALDH) related research. It is particularly valuable for studying the role of ALDH in various biological processes and its potential as a therapeutic target.
Used in Pharmaceutical Industry:
NSC 206120 is used as a research tool in the pharmaceutical industry to investigate the potential of aldehyde dehydrogenase inhibitors as therapeutic agents. Its specificity as an inhibitor allows researchers to explore its potential applications in treating diseases where ALDH plays a significant role.

InChI:InChI=1/C3H4N2O4/c6-3-4(5(7)8)1-2-9-3/h1-2H2

Upstream product

• 497-25-6 dimethylenecyclourethane 
• 43112-38-5 3-(trimethylsilyl)-2-oxazolidinone 
• 5840-81-3 oxazolidine-2-thione 

Downstream Products

• 74386-82-6 2-hydroxyethylnitramine 
• 15719-64-9 methylammonium carbonate 
• 80-65-9 3-amino-2-oxazolidinone 

Relevant articles and documents

Safe and Convenient Synthesis of Primary N -Nitramines in the Freon Media

A convenient one-pot synthesis of primary aliphatic N-nitramines, which includes the nitration of available N,N′-dialkyloxalamides or N-alkylcarbamates with dinitrogen pentoxide in the 1,1,1,2-tetrafluoroethane media followed by ammonolysis of intermediate N-nitroamides in the same solvent has been developed. The method is environmentally safe, and affords target N-nitramines in up to 94% overall yield.

Nitration of carbonic, sulfuric and oxalic acid-derived amides in liquid carbon dioxide

N-Nitro- and N,N'-dinitroamides of carbonic, sulfuric and oxalic acids have been prepared in 76-99% yield by the nitration of the corresponding amides with dinitrogen pentoxide in liquid carbon dioxide.

Clean nitrations: Novel syntheses of nitramines and nitrate esters by nitrodesilylation reactions using dinitrogen pentoxide (N2O5)

In this novel nitration method dinitrogen pentoxide (N2O5) in an inert solvent is used as the nitrating agent, thereby removing the need for strong acids as the reaction medium. The N2O5 cleaves heteroatom-silicon bonds, in silylamines and silyl ethers respectively, to yield the desired energetic groupings (nitramines or nitrate esters respectively) without liberation of acids which would occur with conventional substrates (amines or alcohols). These nitrodesilylation reactions proceed cleanly and in good yield, and the scope of the reaction is illustrated by 29 examples, some of which produce high energy compounds, notably plasticisers and an energetic polymer precursor. These reactions are therefore potentially clean nitrations for the manufacture of energetic compounds which will minimise the impact of this activity on the environment in the future.