852860-46-9

Basic information

• Product Name: diphenyl[1-(toluene-4-sulfonyl)piperidin-4-yl]methanol
• Synonyms: diphenyl[1-(toluene-4-sulfonyl)piperidin-4-yl]methanol
• CAS NO: 852860-46-9
• Molecular Weight: 421.56
• Mol File: 852860-46-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: diphenyl[1-(toluene-4-sulfonyl)piperidin-4-yl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: diphenyl[1-(toluene-4-sulfonyl)piperidin-4-yl]methanol(852860-46-9)
• EPA Substance Registry System: diphenyl[1-(toluene-4-sulfonyl)piperidin-4-yl]methanol(852860-46-9)

Safety Data

• Hazardous Substances Data: 852860-46-9(Hazardous Substances Data)

Upstream product

• 922504-26-5 phenyl(1-tosylpiperidin-4-yl)methanone 
• 37586-22-4 4-benzoylpiperidine 
• 115-46-8 C₁₈H₂₁NO 
• 98-59-9 p-toluenesulfonyl chloride 
• 1620-30-0 diphenyl(pyridin-4-yl)methanol 
• 6071-92-7 VUF 4589 
• 20735-04-0 (1,2,3,6-tetrahydro-1-methylpyridin-4-yl)diphenylmethanol 
• 14548-46-0 4-Benzoylpyridine 
• 100-58-3 phenylmagnesium bromide 
• 112818-77-6 ethyl 4-(hydroxydiphenylmethyl)piperidine-1-carboxylate 

Downstream Products

• 916976-33-5 4-benzhydrylidene-1-(4-methylphenylsulfonyl)-piperidine 
• 22940-59-6 4-benzoyl-4-phenyl-1-(p-toluenesulfonyl)piperidine 

Relevant articles and documents

Synthesis and crystal structure of [1-(toluene-4-sulfonyl)-piperidin-4-yl]- methanol

The title compound, [1-(toluene-4-sulfonyl)-piperidin-4-yl]-methanol was synthesized by the condensation of diphenyl(piperidin-4-yl)methanol with p-toluenesulfonyl chloride in methylene dichloromethane as solvent and triethylamine as the base. The product obtained was characterized by spectroscopic techniques and the structure was investigated by X-ray crystallography. The compound crystallizes in the monoclinic crystal class in the space group P21/c with cell parameters a=10.2490(13) A, b=11.4710(9) A, c=20.997(3) A, =116.344(3), V=2212.2(5) A3 for Z=4. The structure reveals that the piperidine ring is in a chair conformation. The geometry around the S atom is comparable with the classic tetrahedral value. The structure exhibits both inter and intramolecular hydrogen bonds of the type O-HO and C-HO.

CAN-mediated rearrangement of 4-benzhydrylidenepiperidines

Several 1-substituted phenyl-(4-phenylpiperidin-4-yl)methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4-benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog.