851728-99-9Relevant articles and documents
Structure–activity relationship studies of 3-substituted pyrazoles as novel allosteric inhibitors of MALT1 protease
Asaba, Ken Nunettsu,Adachi, Yohei,Tokumaru, Kazuyuki,Watanabe, Akira,Goto, Yasufumi,Aoki, Takumi
, (2021/04/27)
We report the discovery of a novel series of 1,5-bisphenylpyrazoles as potent MALT1 inhibitors. Structure–activity relationship exploration of a hit compound led to a potent MALT1 inhibitor. Compound 33 showed strong activity against MALT1 (IC50/sub
New bicyclic cannabinoid receptor-1 (CB1-R) antagonists
Carpino, Philip A.,Griffith, David A.,Sakya, Subas,Dow, Robert L.,Black, Shawn C.,Hadcock, John R.,Iredale, Philip A.,Scott, Dennis O.,Fichtner, Michael W.,Rose, Colin R.,Day, Robert,Dibrino, Joseph,Butler, Mary,DeBartolo, Demetria B.,Dutcher, Darrin,Gautreau, Denise,Lizano, Jeff S.,O'Connor, Rebecca E.,Sands, Michelle A.,Kelly-Sullivan, Dawn,Ward, Karen M.
, p. 731 - 736 (2007/10/03)
A series of conformationally constrained bicyclic derivatives derived from SR141716 was prepared and evaluated as hCB1-R antagonists and inverse agonists. Optimization of the structure-activity relationships around the 2,6-dihydro-pyrazolo[4,3-
