850568-25-1

Basic information

• Product Name: 4-(PYRIDIN-2-YL)AMINOCARBONYLPHENYLBORONIC ACID
• Synonyms: 4-(PYRIDIN-2-YL-AMINOCARBONYL)BENZENEBORONIC ACID;4-(PYRIDIN-2-YL)AMINOCARBONYLPHENYLBORONIC ACID;N-2-PYRIDINYL 4-BORONOBENZAMIDE;4-(Pyridin-2-yl-aminocarbonyl)benzeneboronic acid 97%;4-(2-PyridylcarbaMoyl)benzeneboronic acid, 97%;(4-(Pyridin-2-ylcarbamoyl)phenyl)boronic acid;4-(Pyridin-2-yl-aminocarbonyl)benzeneboronicacid97%;EOS-61700
• CAS NO: 850568-25-1
• Molecular Formula: C12H11BN2O3
• Molecular Weight: 242.04
• Product Categories: blocks;BoronicAcids
• Mol File: 850568-25-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 124-128
• Appearance: /
• Density: 1.33 g/cm³
• Refractive Index: 1.627
• Storage Temp.: Keep Cold
• PKA: 8.10±0.16(Predicted)
• CAS DataBase Reference: 4-(PYRIDIN-2-YL)AMINOCARBONYLPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PYRIDIN-2-YL)AMINOCARBONYLPHENYLBORONIC ACID(850568-25-1)
• EPA Substance Registry System: 4-(PYRIDIN-2-YL)AMINOCARBONYLPHENYLBORONIC ACID(850568-25-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 850568-25-1(Hazardous Substances Data)

Usage

Physical Form

Solid

Uses

4-(Pyridin-2-yl)aminocarbonylphenylboronic acid is a useful research chemical.

InChI:InChI=1/C12H11BN2O3/c16-12(15-11-3-1-2-8-14-11)9-4-6-10(7-5-9)13(17)18/h1-8,17-18H,(H,14,15,16)

Upstream product

• 5419-55-6 Triisopropyl borate 
• 300401-95-0 4-iodo-N-(pyridin-2-yl)benzamide 
• 14547-83-2 4-bromo-N-(pyridin-2-yl)benzamide 
• 504-29-0 2-aminopyridine 
• 586-76-5 4-Bromobenzoic acid 
• 14047-29-1 4-carboxyphenylboronic acid 

Relevant articles and documents

FURO[3,4-B]PYRROLE-CONTAINING BTK INHIBITOR

The present application belongs to the field of pharmaceutical chemistry, and relates to a furo[3,4-b]pyrrole-containing BTK inhibitor, and in particular, to a compound of formula (I), a stereisomer or pharmacologically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof in treating BTK-related diseases.

Aminonorbornane derivative and preparation method and application thereof

The invention discloses an aminonorbornane derivative and a preparation method and application thereof and relates to a compound having a structure represented by a formula I which is described in thespecification or a pharmaceutically acceptable salt, a solvate, an active metabolite, a polymorph, an ester, an optical isomer or a prodrug thereof, a pharmaceutical composition comprising the compound as shown in the formula I, and application of the compound and the pharmaceutical composition as highly selective Bruton's tyrosine kinase (BTK) inhibitors of BTK (C481S) mutants for preparation ofdrugs used for prevention or treatment of heteroimmune diseases, autoimmune diseases or cancer.

Bruton's tyrosine kinase inhibitor

The invention relates to a compound with a formula I and a pharmaceutically acceptable salt, a solvent compound, an active metabolite, a polycrystalline compound, an ester, an isomer or a prodrug thereof, a pharmaceutical composition containing the compound in the formula I, and application using the same as a selective Bruton's tyrosine kinase inhibitor to prepare a medicine for preventing or treating heterologous immunity diseases and self immunity diseases or cancers. The formula is shown in the specification.