84803-46-3

Basic information

• Product Name: 3-(4-CHLOROPHENYL) GLUTARIMIDE
• Synonyms: 3-(4-CHLOROPHENYL) GLUTARIMIDE;4-(4-chlorophenyl)piperidine-2,6-dione;3-(4-Chloro phenyl) Glutrimide;4-(4-Chlorophenyl)-2,6-piperidinedione;Einecs 284-171-9;4-(4-chlorophenyl)piperidine-2,6-quinone
• CAS NO: 84803-46-3
• Molecular Formula: C₁₁H₁₀ClNO₂
• Molecular Weight: 223.66
• EINECS: 284-171-9
• Product Categories: Aromatics;Heterocycles
• Mol File: 84803-46-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 160 °C(Solv: toluene (108-88-3))
• Boiling Point: 418.7 °C at 760 mmHg
• Flash Point: 207 °C
• Appearance: /
• Density: 1.303 g/cm³
• Vapor Pressure: 3.21E-07mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 11.30±0.40(Predicted)
• CAS DataBase Reference: 3-(4-CHLOROPHENYL) GLUTARIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENYL) GLUTARIMIDE(84803-46-3)
• EPA Substance Registry System: 3-(4-CHLOROPHENYL) GLUTARIMIDE(84803-46-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 84803-46-3(Hazardous Substances Data)

Usage

Description

3-(4-CHLOROPHENYL) GLUTARIMIDE, also known as 4-(4-Chlorophenyl)-2,6-piperidinedione, is an off-white solid compound with the chemical formula C11H10ClNO3. It is a useful compound in organic synthesis and has a CAS number of 84803-46-3.

Uses

Used in Organic Synthesis:
3-(4-CHLOROPHENYL) GLUTARIMIDE is used as a synthetic intermediate for the production of various organic compounds. Its unique structure and functional groups make it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(4-CHLOROPHENYL) GLUTARIMIDE is used as a key intermediate in the synthesis of various drug molecules. Its presence in the molecular structure can impart specific biological activities and properties, making it an essential component in the development of new therapeutic agents.
Used in Agrochemical Industry:
3-(4-CHLOROPHENYL) GLUTARIMIDE is also utilized in the agrochemical industry as a precursor for the synthesis of various agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, thereby contributing to increased crop yields and agricultural productivity.

InChI:InChI=1/C11H10ClNO2/c12-9-3-1-7(2-4-9)8-5-10(14)13-11(15)6-8/h1-4,8H,5-6H2,(H,13,14,15)

Upstream product

• 35271-74-0 3-(4-chlorophenyl)pentane-1,5-dioic acid 
• 19411-80-4 2-(4-chlorophenylmethylene)acetoacetic acid ethyl ester 
• 101104-10-3 diethyl 3-(4-chlorophenyl)glutarate 
• 84803-73-6 C₁₉H₂₃ClO₆ 
• 104-88-1 4-chlorobenzaldehyde 
• 57-13-6 urea 

Downstream Products

• 1312808-93-7 1-(2-chloroethyl)-4-(4-chlorophenyl)piperidine-2,6-dione 
• 1312809-12-3 4-(4-chlorophenyl)-1-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]piperidine-2,6-dione 
• 1312809-13-4 4-(4-chlorophenyl)-1-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]piperidine-2,6-dione 
• 1312809-14-5 4-(4-chlorophenyl)-1-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]piperidine-2,6-dione 
• 1312809-15-6 4-(4-chlorophenyl)-1-[3-[4-(2-chlorophenyl)piperazin-1-yl]propyl]piperidine-2,6-dione 
• 1312809-16-7 4-(4-chlorophenyl)-1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]piperidine-2,6-dione 
• 1312808-91-5 4-(4-chlorophenyl)-1-(2-hydroxyethyl)piperidine-2,6-dione 
• 1312808-97-1 4-(4-chlorophenyl)-1-(3-chloropropyl)piperidine-2,6-dione 
• 1141-23-7 3-(p-chlorophenyl)glutaramic acid 

Relevant articles and documents

A balufen green industrial production method (by machine translation)

The invention discloses a balufen green preparation method, which belongs to the technical field of drug synthesis. The method to the chlorobenzene as a starting material, by Knoevenagel condensation, alkali hydrolysis, sub-amide, alkali hydrolysis and Hofmann degradation 5 step reaction make the consistent with the clinical pharmaceutical balufen. Raw materials of this invention extremely easy, low cost, simple synthesis operation, are basically all aqueous reaction under the condition of, environmental pollution is very small, high yield, is a brand new industrial production balufen method. (by machine translation)

Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α1-adrenoceptor subtypes

A number of new 4-phenylpiperidine-2,6-diones bearing at the 1-position an ω-[4-(substituted phenyl)piperazin-1-yl]alkyl moiety were designed and synthesized as ligands for the α1-adrenergic receptor (α1-AR) subtypes. Some synthesized compounds, tested in binding assays for the human cloned α1A-, α1B-, and α1D-AR subtypes, displayed affinities in the nanomolar range. Highest affinity values were found in derivatives having a butyl connecting chain between the 4-phenylpiperidine-2,6-dione and the phenylpiperazinyl moieties. 1-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]-4-phenylpiperidine-2,6- dione (34) showed the best affinity for the α1A-AR (pKi= 8.74) and 10-fold selectivity compared to the other two α1-AR subtypes. Some representative compounds were also tested in order to evaluate their effects on the signal transduction pathway coupled to α1-AR subtypes. They all blocked norepinephrine-induced stimulation of inositol phospholipid hydrolysis, thus behaving as antagonists. Binding data were used to refine a previously developed pharmacophoric model for α1D-ARs. The revised model shows a highly predictive power and could be useful for the future design of high affinity α1D-AR ligands.