847729-27-5

Basic information

• Product Name: METHYL2-CHLORO-5-FLUORONICOTINATE
• Synonyms: METHYL2-CHLORO-5-FLUORONICOTINATE;2-Chloro-5-fluoro-nicotinic acid Methyl ester;methyl 2-chloro-5-fluoropyridine-3-carboxylate
• CAS NO: 847729-27-5
• Molecular Formula: C₇H₅ClFNO₂
• Molecular Weight: 189.57
• Mol File: 847729-27-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 235.4°C at 760 mmHg
• Flash Point: 96.2°C
• Appearance: /
• Density: 1.386g/cm³
• Vapor Pressure: 0.0502mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -3.73±0.10(Predicted)
• CAS DataBase Reference: METHYL2-CHLORO-5-FLUORONICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL2-CHLORO-5-FLUORONICOTINATE(847729-27-5)
• EPA Substance Registry System: METHYL2-CHLORO-5-FLUORONICOTINATE(847729-27-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 847729-27-5(Hazardous Substances Data)

Usage

Uses

Methyl 2-chloro-5-fluoronicotinate

InChI:InChI=1/C7H5ClFNO2/c1-12-7(11)5-2-4(9)3-10-6(5)8/h2-3H,1H3

Upstream product

• 38186-88-8 2-chloro-5-fluoronicotinic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 74-88-4 methyl iodide 

Downstream Products

• 868636-57-1 methyl 5-fluoro-2-methylnicotinate 
• 1380753-55-8 methyl 5-fluoro-2-(3-((4-fluoro-2-methylphenyl)amino)azetidin-1-yl)nicotinate 
• 870063-52-8 2-chloro-3-hydroxymethyl-5-fluoropyridine 
• 884494-82-0 5-fluoro-2-methoxy-pyridine-3-carboxylic acid 
• 874822-98-7 (5-fluoro-2-methoxypyridin- 3-yl)methanol 

Relevant articles and documents

EIF4E INHIBITORS AND USES THEREOF

The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.

PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS

The invention relates pyridine amide derivative of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, linear o branched (C1-C3)alkyl or joined together they form a cyclopropyl ring; R is independently selected from the group consisting of halogens and trifluoromethyl and p is 1, 2 or 3; A is C or N; E is a group of formula (B) or (C), wherein B is C(O)OH, C(O)O(C1-C3)alkyl, and C is selected from the group consisting of formula (I) m is 1,2 or 3, n is 0 or 1, W is -O-, -O(C1-C3 alkyl)-; -(C1-C3 alkyl)O-; -C(O)-; -C(=N-O(C1-C3 alkyl))-; -NH- or -NH(C1-C3alkyl)-; Ar is phenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, methyl, -NH(C1-C3alkyl)-; -N(C1-C3alkyl)(C1-C3alkyl)-, a from 5 to 7 membered heterocyclic ring containing one nitrogen atom which is convalently bonded to Ar and optionally containing one or two heteroatoms selected from N, O and S; and a 5- or 6-membered heteroaromatic ring containing 1 to 3 heteroatoms selected from S, O e N, such heteroaromatic ring being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl. The compounds of the invention could be used for manufacturing a medicament for the treatment of pathologies which require the use of an antagonist of the EP4 receptor, such as the treatment of acute and chronic pain, inflammatory pain, osteoarthritis, inflammation-associated disorder as arthritis, rheumatoid artrhritis, cancer, endometriosis and migraine.

COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS

The instant invention relates to a combination of an EP4-receptor antagonist and an alpha-2-delta ligand, and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly inflammatory,