83747-30-2

Basic information

• Product Name: 3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID
• Synonyms: 3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID;3-(1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONIC ACID;3-(1-Oxoisoindolin-2-yl)propanoic acid
• CAS NO: 83747-30-2
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.21
• Mol File: 83747-30-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 447.9 °C at 760 mmHg
• Flash Point: 224.7 °C
• Appearance: /
• Density: 1.325 g/cm³
• Vapor Pressure: 8.34E-09mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID(83747-30-2)
• EPA Substance Registry System: 3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID(83747-30-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 83747-30-2(Hazardous Substances Data)

Usage

General Description

3-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid is a chemical compound with a complex structure. 3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID falls under the category of isoindolines, which are polycyclic compounds containing an isoindoline moiety (a partially saturated indole fused with a cyclohexene) and its hydrogenated derivatives. It contains a 1-Oxo-1,3-dihydro-2H-isoindol-2-yl group connected to a propanoic acid. The accurate chemical information, such as physical and chemical properties, synthesis routes, stability, or toxicity of this particular compound, may be less explored or documented, primarily if it is a novel or less-common compound. As per its nomenclature, it seems to be an intermediate compound used for further complex chemical synthesis in organic chemistry.

InChI:InChI=1/C11H11NO3/c13-10(14)5-6-12-7-8-3-1-2-4-9(8)11(12)15/h1-4H,5-7H2,(H,13,14)

Upstream product

• 887643-32-5 N-(2-carboxybenzomethyl)-β-alanine 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 107-95-9 3-amino propanoic acid 
• 3339-73-9 3-phthalimidopropanoic acid 
• 4561-06-2 ethyl 3-(1,3-dioxoisoindolin-2-yl)propanoate 

Downstream Products

• 1447331-52-3 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid methyl ester 
• 1447330-37-1 3-[1-oxo-6-(3-piperazinium-1-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]propionic acid trifluoroacetate 
• 1447332-02-6 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid 
• 620099-68-5 3-(6-nitro-1-oxo-1,3-dihydroisoindol-2-yl)propionic acid 

Relevant articles and documents

A novel copper(II) coordination polymer with carboxylate and isoindol backbones of a bifunctional ligand

The reaction of a bifunctional ligand, 3-(1-oxo-1,3-dihydro-isoindol-2-yl)- propionic acid (Hpda) with Cu(NO3)2 3H 2O in methanol-water in the presence of NaOH at room temperature produces a novel dinuclear copper(II) coordination polymer [Cu 2(pda)4]n. The complex is fully characterized in the solid state as well as in solution using various analytical techniques including single crystal X-ray diffraction study. The single crystal X-ray structure analysis reveals that the monomeric unit of complex consists of Cu2(O2CR)4 paddlewheel building unit, where the two copper centers acquire a distorted square pyramidal geometry with amide oxygen of the isoindol ring of an adjacent Hpda ligand sitting on the axial positions.

RGD mimetics containing phthalimidine fragment as novel ligands of fibrinogen receptor

The novel RGD mimetics with phthalimidine central fragment were synthesized with the use of 4-piperidine-4-yl-butyric, 4-piperidine-4-yl-benzoic, 4-piperazine-4-yl-benzoic and 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acids as surrogates of Arg motif. T

Hypolipidemic activity of phthalimide derivatives. 3. A comparison of phthalimide and 1,2-benzisothiazolin-3-one 1,1-dioxide derivatives to phthalimidine and 1,2-benzisothiazoline 1,1-dioxide congeners

Previously it has been observed that N-substituted phthalimide derivatives with chain lengths of four carbon or oxygen atoms showed potent hypolipidemic activity in rodents at 20 (mg/kg)/day ip. The 1,2-benzisothiazolin-3-one 1,1-dioxide (saccharin) nucleus, itself, had also been observed to be active at the same dose. An investigation was undertaken to examine a series of 1,2-benzisothiazolin-3-one 1,1-dioxide analogues for their hypolipidemic activity in mice and to compare them to their respective phthalimide congeners. In addition, a series of 1,2-benzisothiazoline 1,1-dioxide and phthalimidine analogues was prepared, and their hypolipidemic activity was compared to the phthalimide analogues. These studies show that the respective congeners of 1,2-benzisothiazolin-3-one 1,1-dioxide compared favorably to phthalimide congeners in reducing serum triglyceride and cholesterol levels in male CF1 mice at 20 (mg/kg)/day ip. Of the saccharin derivatives, 3-oxo-1,2-benzisothiazoline-2-propionic acid 1,1-dioxide was the most effective in lowering serum cholesterol levels by 53% after 16 days dosing and 3-oxo-1,2-dibenzothiazoline-2-valeric acid 1,1-dioxide lowered serum triglycerides 56% after 14 days dosing. The 1,2-benzisothiazoline 1,1-dioxide and phthalimidine compounds were less active as hypolipidemic agents than their 1,2-benzisothiazolin-3-one 1,1-dioxide and phthalimide analogues, respectively.