829-20-9

Basic information

• Product Name: 2,4-Dimethoxyacetophenone
• Synonyms: 2',4'-DIMETHOXYACETOPHENONE;2,4-DIMETHOXYACETOPHENONE;AKOS BBS-00004235;1-(2,4-Dimethoxy-phenyl)-ethanone;Acetophenone, 2',4'-dimethoxy-;Ethanone, 1-(2,4-dimethoxyphenyl)-;2',4'-Dimethoxyacethophenone, 98%;1-Acetyl-2,4-dimethoxybenzene
• CAS NO: 829-20-9
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• EINECS: 212-587-2
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Acetophenone series;Building Blocks;C10;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks
• Mol File: 829-20-9.mol
• Article Data: 62

Chemical Properties

• Melting Point: 37-40 °C(lit.)
• Boiling Point: 288 °C(lit.)
• Flash Point: >230 °F
• Appearance: White to off-white/Crystalline Powder
• Density: 1.1272 (rough estimate)
• Refractive Index: 1.5430 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive: Light Sensitive
• BRN: 511947
• CAS DataBase Reference: 2,4-Dimethoxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethoxyacetophenone(829-20-9)
• EPA Substance Registry System: 2,4-Dimethoxyacetophenone(829-20-9)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 829-20-9(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white crystalline powder

Preparation

Obtained by reaction of dimethyl sulfate with resacetophenone in the presence of 10% aqueous sodium hydroxide (61%).

InChI:InChI=1/C10H12O3/c1-7(11)9-5-4-8(12-2)6-10(9)13-3/h4-6H,1-3H3

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 75-03-6 ethyl iodide 
• 64-19-7 acetic acid 
• 151-10-0 1,3-Dimethoxybenzene 
• 75-36-5 acetyl chloride 
• 77-78-1 dimethyl sulfate 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 74-88-4 methyl iodide 
• 86774-68-7 1H,3H-2,4,6-trimethyl-1,3,5-triazinium triflate 
• 3066-75-9 allyl diethyl phosphate 
• 125304-87-2 (E)-1-(2,4-dimethoxyphenyl)ethan-1-one O-methyl oxime 
• 186581-53-3 diazomethane 
• 1124-53-4 N-cyclohexylacetamide 
• 108-46-3 recorcinol 

Downstream Products

• 23423-35-0 (E)‐3‐(4‐hydroxyphenyl)‐1‐(2,4‐dimethoxyphenyl)prop‐2‐en‐1‐one 
• 66346-54-1 1-(2,4-dimethoxy-phenyl)-hexane-1,3-dione 
• 6665-54-9 1-(2,4-dimethoxy-phenyl)-5t-phenyl-penta-2t,4-dien-1-one 
• 1911-68-8 2-hydroxy-4.2'.4'-trimethoxy-trans-chalcone 
• 62536-73-6 3-hydroxy-4,2',4'-trimethoxy-trans-chalcone 
• 13330-65-9 2,4-dimethoxyphenol 
• 17736-45-7 2,4-dimethoxy-1-(prop-1-en-2-yl)benzene 
• 107412-17-9 3-(2,4-dimethoxyphenyl)-N,N-dimethyl-3-oxo-1-propanamine hydrochloride 
• 102172-32-7 5-(2,4-dimethoxy-phenyl)-5-oxo-3-phenyl-valeric acid 
• 80370-26-9 1-(2,4-dimethoxyphenyl)-3-phenyl-1,3-propanedione 

Relevant articles and documents

Peptoid Helix Displaying Flavone and Porphyrin: Synthesis and Intramolecular Energy Transfer

Natural light-harvesting complexes (LHCs) absorb a broad spectrum of sunlight using a collection of photosynthetic pigments whose spatial arrangement is controlled by a protein matrix and exhibit efficient energy transfer. We constructed a novel light-harvesting protein mimic, which absorbs light in the UV to visible region (280-700 nm) by displaying flavone and porphyrin on a peptoid helix. First, an efficient synthesis of 4′-derivatized 7-methoxyflavone (7-MF, 3 and 4) was developed. The flavone-porphyrin-peptoid conjugate (FPPC) was then prepared via Miyaura borylation on a resin-bound peptoid followed by Suzuki coupling between the peptoid and pigment. Circular dichroism spectroscopy indicated that the FPPC underwent helix-to-loop conversion of the peptoid scaffold upon changing the solvent conditions. A distinct intramolecular energy transfer was observed from 7-MF to porphyrin with greater efficiency in the helix than that in the loop conformation of the peptoid, whereas no clear evidence of energy transfer was obtained for unstructured FPPC. We thus demonstrate the value of the helical peptoid, which provided a controlled orientation for 7-MF and porphyrin and modulated the energy transfer efficiency via conformational switching. Our work provides a way to construct a sophisticated LHC mimic with enhanced coverage of the solar spectrum and controllable energy transfer efficiency.

Preparation method of S-configuration phenyl ethyl amine hydrochloride compound

The invention relates to a preparation method of an S-configuration phenyl ethyl amine hydrochloride compound, and relates to the technical field of medicine synthesis and preparation. The preparationmethod comprises the following steps: (1) carrying out Friedel-Crafts reaction on m-dimethoxy benzene and acetyl chloride under the condition of Lewis acid to generate an intermediate A; (2) reactingthe intermediate A with hydroxylamine hydrochloride without separation to generate an intermediate B; (3) reducing the intermediate B under the condition of a reducing agent to obtain a compound C; (4) carrying out organic acid resolution on the compound C to obtain an S-configuration compound D organic salt; and (5) dissociating and salifying the organic salt to obtain a target product compoundE. The preparation method disclosed by the invention has the characteristics of simple purification, low cost, high efficiency, high yield and suitability for industrial mass production.

STRONGLY LEWIS ACIDIC METAL-ORGANIC FRAMEWORKS FOR CONTINUOUS FLOW CATALYSIS

Lewis acidic metal-organic framework (MOF) materials comprising triflate-coordinated metal nodes are described. The materials can be used as heterogenous catalysts in a wide range of organic group transformations, including Diels-Alder reactions, epoxide-ring opening reactions, Friedel-Crafts acylation reactions and alkene hydroalkoxylation reactions. The MOFs can also be prepared with metallated organic bridging ligands to provide heterogenous catalysts for tandem reactions and/or prepared as composites with support particles for use in columns of continuous flow reactor systems. Methods of preparing and using the MOF materials and their composites are also described.