826-36-8 Usage
Description
Triacetonamine, also known as 2,2,6,6-Tetramethyl-4-piperidinone, is a white crystalline powder with a melting point of 43°C and a boiling point of 205°C. It is soluble in acetone, alcohol, ether, and water. It is an intermediate and pharmaceutical intermediate of histamine light stabilizer and possesses a light-stabilizing effect itself. It has important applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Triacetonamine is used as an intermediate and pharmaceutical intermediate for the synthesis of histamine light stabilizers. Its light-stabilizing effect makes it a valuable component in the development of pharmaceutical products.
Used in Organic Synthesis:
Triacetonamine is a compound useful in organic synthesis, contributing to the creation of various chemical compounds and products.
Chemical Properties:
Triacetonamine appears as a white or light yellow powder and is soluble in acetone, alcohol, ether, and water. Its melting point is 43°C, and its boiling point is 205°C.
Triacetone amine
Triacetonamine has anti-arrhythmic and anti-myocardial ischemia effect.
Take Triacetonamine as raw materials, ethanol as the solvent, perform hydrogenation reaction in the presence of catalyst (normal pressure or 3~4MPa) and obtain raw material of histamine-type light stabilizer 2,2,6,6-tetramethyl-4-piperidinol.
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Synthesis Reference(s)
Synthesis, p. 735, 1976 DOI: 10.1055/s-1976-24178
Check Digit Verification of cas no
The CAS Registry Mumber 826-36-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,2 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 826-36:
(5*8)+(4*2)+(3*6)+(2*3)+(1*6)=78
78 % 10 = 8
So 826-36-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H15NO3/c1-7(11)4-10(5-8(2)12)6-9(3)13/h4-6H2,1-3H3
826-36-8Relevant articles and documents
Preparation of triacetoneamine, an improved method
Wu, Anxin,Yang, Weidong,Pan, Xinfu
, p. 3565 - 3569 (1996)
A new method for the preparation of triacetoneamine has been developed, in which, p-nitrotoluene is used as a catalyst, the yield of triacetoneamine is up to 65%.
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Rozantsev,Ivanov
, (1971)
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Method for preparing triacetone amine
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Paragraph 0133-0144, (2020/07/05)
An improved method is used for preparing triacetone amine while recycling the by-products. This involves treating the crude product from triacetone amine preparation, which leads to an increase in the content of compounds which react readily with ammonia. This method enables efficient recycling of the by-products formed in the synthesis of triacetone amine.
Method for preparing intermediate 2,2,6,6-tetramethyl-4-piperidylamine
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Paragraph 0039; 0040; 0041; 00443;, (2019/12/25)
The invention relates to a method for preparing intermediate 2,2,6,6-tetramethyl-4-piperidylamine. The method is characterized by comprising the following steps: step 1), in the presence of a catalyst1, reacting acetone with ammonia gas to produce 2,2,6,6-tetramethyl-4-piperidinone and water; and step 2), in the presence of a catalyst 2, reacting the 2,2,6,6-tetramethyl-4-piperidinone with ammonia gas to produce 2,2,6,6-tetramethyl-4-piperidylimine and water, and reacting the 2,2,6,6-tetramethyl-4-piperidylimine with hydrogen gas to produce the 2,2,6,6-tetramethyl-4-piperidylamine, wherein the catalyst 1 is ammonium nitrate, and the catalyst 2 is a sodium hydroxyphenyl phosphate modified framework nickel catalyst. The method provided by the invention has the advantages of short synthetictime, a high conversion rate of the acetone and a high repeating utilization rate of the raw materials.