825643-73-0

Basic information

• Product Name: 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide
• Synonyms: 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide
• CAS NO: 825643-73-0
• Molecular Weight: 532.888
• Mol File: 825643-73-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 504.6±50.0 °C(Predicted)
• Density: 1.353±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide(825643-73-0)
• EPA Substance Registry System: 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide(825643-73-0)

Safety Data

• Hazardous Substances Data: 825643-73-0(Hazardous Substances Data)

Usage

Chemical structure

A synthetic nucleoside analogue

Function

Antiviral and anticancer medication

Mechanism of action

Inhibits the replication of viral and cancerous DNA within infected or abnormal cells, leading to their destruction

Common uses

Treatment of herpes simplex keratitis (a viral infection of the eye) and certain types of cancer, particularly colorectal and gastrointestinal cancers

Administration

Eye drop or injection under expert medical supervision

Precautions

Potent and potentially harmful effects if not used properly

Upstream product

• 74-88-4 methyl iodide 
• 289686-69-7 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride 
• 825643-59-2 (6-chloro-4-iodopyridin-3-yl) methylamine 
• 825643-58-1 (6-chloro-4-iodopyridine-3-yl)methylcarbamic acid tert-butyl ester 
• 400777-00-6 (6-chloro-4-iodopyridin-3-yl)carbamic acid tert-butyl ester 
• 171178-45-3 tert-butyl (6-chloropyridin-3-yl)carbamate 
• 289686-70-0 α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid 

Relevant articles and documents

NEW CHEMICAL PROCESS FOR MAKING 6-CHLORO-4-(4-FLUORO-2-METHYLPHENYL)PYRIDIN-3-AMINE A KEY INTERMEDIATE OF NT-814

The invention relates to a new process for producing compound 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide (Compound IX) which is useful in the manufacture of compound 2-[3,5-Bis(trifluoro

Cyclohexylpropionic polypyridine deriv.

A problem of the present invention is to provide a new compound which has NK 1 receptor antagonist activity ,whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; R 1 is carboxymethyl or the like; R 2 is alkyl or the like; Y is 0-2 or the like; U is-N(CH 3 )COC(CH 3 ) 2 -3,5-bistrifluoromethylphenyl or the like.

Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia

The present invention relates to a method of treating schizophrenia which comprises administering a therapeutically effective amount of a compound of formula I wherein R1, R2, and R3 are as defined in the specification or to pharmaceutically active acid-addition salts thereof.