82219-78-1 Usage
Description
Cefuzonam is an injectable cephalosporin antibiotic that exhibits activity against a significant proportion of Gram-negative bacteria and certain Gram-positive bacteria, including strains resistant to other third-generation cephalosporins.
Uses
Used in Pharmaceutical Industry:
Cefuzonam is used as an antibiotic for the treatment of various bacterial infections caused by susceptible organisms. Its broad-spectrum activity makes it a valuable option for treating infections where the causative pathogen is unknown or resistant to other commonly used antibiotics.
Check Digit Verification of cas no
The CAS Registry Mumber 82219-78-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,2,1 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 82219-78:
(7*8)+(6*2)+(5*2)+(4*1)+(3*9)+(2*7)+(1*8)=131
131 % 10 = 1
So 82219-78-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H15N7O5S4.Na.2H2O/c1-28-21-9(7-5-31-16(17)19-7)12(24)20-10-13(25)23-11(15(26)27)6(4-30-14(10)23)3-29-8-2-18-22-32-8;;;/h2,5,10,14H,3-4H2,1H3,(H2,17,19)(H,20,24)(H,26,27);;2*1H2/q;+1;;/p-1/b21-9-;;;
82219-78-1Relevant articles and documents
NOVEL INTERMEDIATES FOR SYNTHESIS OF CEPHALOSPORINS AND PROCESS FOR PREPARATION OF SUCH INTERMEDIATES
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Page 33, (2008/06/13)
A novel 4-halo-2-oxyimino-3-oxo butyric acid-N, N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics, wherein X is chlorine or bromine; R is hydrogen, C1-4 alkyl group, an easily removable hydroxyl protective group, -CH2COOR5, or -C(CH3)2COOR5, wherein R5 is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV1), wherein X, R and R5 are as defined above, with N, N-dimethylformiminium chloride chlorosulphate of formula (VII), in an organic solvent at a temperature ranging from -30 °C to -15 °C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.