816458-31-8

Basic information

• Product Name: Tecovirimat
• Synonyms: tecovirimat;rel-N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)benzamide
• CAS NO: 816458-31-8
• Molecular Formula: C19H15F3N2O3
• Molecular Weight: 376.332
• Mol File: 816458-31-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 194-195 ºC
• Appearance: /
• Density: 1.53
• Storage Temp.: -20°C Freezer
• Solubility: Dichloromethane (Slightly), DMSO Slightly()
• CAS DataBase Reference: Tecovirimat(CAS DataBase Reference)
• NIST Chemistry Reference: Tecovirimat(816458-31-8)
• EPA Substance Registry System: Tecovirimat(816458-31-8)

Safety Data

• Hazardous Substances Data: 816458-31-8(Hazardous Substances Data)

Usage

Uses

Tecovirimat is an orally bioavailable antipoxvirus compound inhibits extracellular virus formation and protects mice from lethal orthopoxvirus, including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), and variola viruses.

Upstream product

• 339-59-3 4-(trifluoromethyl)benzoic acid hydrazide 
• 1565736-80-2 N-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-4-(trifluoromethyl)benzamide 
• 544-25-2 Cyclohepta-1,3,5-triene 
• 944-41-2 (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-hexahydro-4,6-etheno-1H-cycloprop[f]isobenzofuran-1,3(3aH)-dione 
• 1565736-79-9 C₁₁H₁₂N₂O₂*ClH 
• 1711-02-0 4-iodobenzoic acid chloride 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 1565736-87-9 C₁₈H₁₅IN₂O₃ 
• 1565736-74-4 C₁₆H₂₀N₂O₄ 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 
• 7131-63-7 Tricyclo<3.2.2.0^2,4>non-8-en-endo-6,endo-7-dicarbonsaeureanhydrid 

Relevant articles and documents

PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT AND PREVENTION OF ORTHOPOXVIRUS INFECTIONS AND ASSOCIATED DISEASES

Pharmaceutical compositions containing di, tri, and tetracyclic acylhydrazide derivatives of the formula below, for use in the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

Polymorphic Forms of ST-246 and Methods of Preparation

Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.