81216-13-9

Basic information

• Product Name: 1-Octyne, 8-broMo-
• Synonyms: 1-Octyne, 8-broMo-;8-broMo-1-octyne
• CAS NO: 81216-13-9
• Molecular Formula: C₈H₁₃Br
• Molecular Weight: 189.09282
• Mol File: 81216-13-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 201.5±23.0 °C(Predicted)
• Appearance: /
• Density: 1.200±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Octyne, 8-broMo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Octyne, 8-broMo-(81216-13-9)
• EPA Substance Registry System: 1-Octyne, 8-broMo-(81216-13-9)

Safety Data

• Hazardous Substances Data: 81216-13-9(Hazardous Substances Data)

Usage

Description

1-Octyne, 8-bromo-, also known as 8-Bromooct-1-yne, is a six-carbon reagent that features an alkyne group and a bromide group. This unique structure allows it to participate in Click Chemistry reactions with azide-bearing compounds or biomolecules under the catalysis of copper, making it a versatile molecule for various applications in chemical synthesis and bioconjugation.

Uses

Used in Chemical Synthesis:
1-Octyne, 8-bromois used as a building block in chemical synthesis for the creation of complex organic molecules. Its alkyne and bromide groups provide multiple sites for further chemical reactions, enabling the formation of a wide range of compounds.
Used in Bioconjugation:
In the field of bioconjugation, 1-Octyne, 8-bromoserves as a linker molecule to attach biologically relevant molecules, such as peptides, proteins, or nucleic acids, to other chemical entities. Its reactivity in Click Chemistry reactions facilitates the formation of stable and specific conjugates, which is crucial for applications in drug development, diagnostics, and research.
Used in Drug Development:
1-Octyne, 8-bromois utilized as a key intermediate in the synthesis of pharmaceutical compounds. Its ability to participate in Click Chemistry reactions allows for the efficient and selective construction of drug candidates with desired properties, such as improved pharmacokinetics, target specificity, and reduced side effects.
Used in Materials Science:
In materials science, 1-Octyne, 8-bromois employed in the development of novel materials with tailored properties. Its alkyne and bromide groups can be incorporated into polymers, dendrimers, or other macromolecular structures, leading to materials with unique characteristics, such as enhanced stability, responsiveness to stimuli, or specific binding capabilities.
Overall, 1-Octyne, 8-bromois a valuable reagent in various scientific and industrial fields due to its unique structure and reactivity in Click Chemistry reactions. Its applications span from chemical synthesis and bioconjugation to drug development and materials science, highlighting its versatility and potential for future discoveries.

Upstream product

• 871-91-0 oct-7-yn-1-ol 
• 629-03-8 1 ,6-dibromohexane 
• 1066-26-8 sodium acetylide 
• 14916-80-4 oct-3-yn-1-ol 
• 871-84-1 1,7-Octadiyne 
• 20739-58-6 2-octyn-1-ol 
• 228403-45-0 oct-7-ynyl methanesulfonate 
• 219982-82-8 7-octyne-1-yl 4-methylbenzene sulfonate 
• 90111-60-7 1-bromoocta-1,7-diyne 

Downstream Products

• 14502-43-3 8-aminooct-1-yne 
• 133188-94-0 Non-2-ynylsulfanyl-benzene 
• 111-65-9 octane 
• 39750-95-3 hexadeca-1,15-diyne 
• 629-05-0 n-octyne 
• 544-76-3 Hexadecane 
• 629-74-3 hexadec-1-yne 
• 81168-87-8 1,8-Dibromo-1-octyne 
• 186670-53-1 methyl 2-methoxy-6-(8-nonynyl)benzoate 
• 228403-26-7 C₁₈H₂₄O₃ 
• 326593-26-4 C₃₆H₄₆O₆ 
• 228403-31-4 C₃₆H₅₀O₆ 
• 326593-31-1 C₅₂H₇₄O₆ 
• 228403-35-8 C₅₂H₇₂O₆ 

Relevant articles and documents

Synthesis of a pH-Sensitive Hetero[4]Rotaxane Molecular Machine that Combines [c2]Daisy and [2]Rotaxane Arrangements

The synthesis of a novel pH-sensitive hetero[4]rotaxane molecular machine through a self-sorting strategy is reported. The original tetra-interlocked molecular architecture combines a [c2]daisy chain scaffold linked to two [2]rotaxane units. Actuation of the system through pH variation is possible thanks to the specific interactions of the dibenzo-24-crown-8 (DB24C8) macrocycles for ammonium, anilinium, and triazolium molecular stations. Selective deprotonation of the anilinium moieties triggers shuttling of the unsubstituted DB24C8 along the [2]rotaxane units.

Nucleic acid base analogs with quenching and fluorescent activities and applications thereof

It is an object of the present invention to provide quenching or fluorescent nucleic acid base analogs and applications thereof. The quencher of the present invention has a 2-nitropyrrole structure represented by Formula I: [Formula 1] (in Formula I, Rsu

Effects of substitution and terminal groups for liquid-crystallinity enhanced luminescence of disubstituted polyacetylenes carrying chromophoric terphenyl pendants

Liquid-crystalline and light-emitting poly(2-alkyne)s containing terphenyl cores with hexamethyleneoxy spacers, and cyano or n-propoxy tails - [CH3C=C(CH2)6O-terphenyl-R] n -, where R=CN, CH3PA6CN, R=OCH2CH 2CH3, CH3PA6OPr, were synthesized. The effects of the substitution and terminal groups on the properties, especially the mesomorphic and optical properties of the polymers, were investigated. The disubstituted acetylene monomers (CH3A6CN, CH3A6OPr) were prepared through multistep reaction routes and were polymerized by WCl6-Ph4Sn in good yields (up to 82%). All the monomers and CH3PA6CN exhibited the enantiotropic SmA phase with a monolayer arrangement at elevated temperatures, whereas CH3PA6OPr formed a bilayer SmAd packing arrangement. Upon excitation at 330 nm, strong UV and blue emission peaks at 362 and 411 nm were observed in CH3PA6OPr and CH3PA6CN, respectively. The luminescent properties of CH3PA6CN and CH3PA6OPr have been improved by introducing the methyl substituted group, and the quantum yield of the polymer with cyano tail CH3PA6CN (Φ = 74%) was found to be higher than that of CH3PA6OPr (Φ = 60%). Compared to polyacetylene parents, both CH3PA6OPr and CH3PA6CN showed a narrower energy gap. This demonstrated that the electrical conductivities of polyacetylenes could be enhanced by attaching appropriate pendants to the conjugated polyene backbones.