812-18-0

Basic information

• Product Name: 2,2,2-TRIFLUORO-1,1-DIMETHYL-ETHYLAMINE
• Synonyms: 2,2,2-TRIFLUORO-1,1-DIMETHYL-ETHYLAMINE;1,1,1-trifluoro-2-Methylpropan-2-aMine;2,2,2-Trifluoromethyl-1,1-dimethyl-ethylamine
• CAS NO: 812-18-0
• Molecular Formula: C₄H₈F₃N
• Molecular Weight: 127.11
• Mol File: 812-18-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 81 °C at 760 mmHg
• Flash Point: 12.2 °C
• Appearance: /
• Density: 1.108 g/cm³
• PKA: 6.17±0.50(Predicted)
• CAS DataBase Reference: 2,2,2-TRIFLUORO-1,1-DIMETHYL-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUORO-1,1-DIMETHYL-ETHYLAMINE(812-18-0)
• EPA Substance Registry System: 2,2,2-TRIFLUORO-1,1-DIMETHYL-ETHYLAMINE(812-18-0)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• Hazardous Substances Data: 812-18-0(Hazardous Substances Data)

Usage

Description

2,2,2-Trifluoro-1,1-dimethyl-ethylamine, also known as 2-trifluoromethylpropan-2-amine, is an organic compound with a unique structure featuring a trifluoromethyl group and an amine functional group. It is characterized by its high reactivity and stability, making it a valuable intermediate in the synthesis of various pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
2,2,2-Trifluoro-1,1-dimethyl-ethylamine is used as a reagent for the discovery of hepatitis C virus inhibitors. Its unique structure allows it to interact with specific viral enzymes, thereby inhibiting the replication of the virus and providing a potential treatment for hepatitis C.
Used in Inflammatory Disease Treatment:
2,2,2-Trifluoro-1,1-dimethyl-ethylamine is also used as a selective inhibitor of PI3K (phosphoinositide 3-kinase), a key enzyme involved in the inflammatory response. By inhibiting PI3K, this compound can help reduce inflammation and alleviate symptoms associated with various inflammatory diseases.

Upstream product

• 354-38-1 2,2,2-trifluoroacetamide 
• 917-54-4 methyllithium 
• 62-57-7 2-Aminoisobutyric acid 

Downstream Products

• 1352087-16-1 4-nitrophenyl 1,1,1-trifluoro-2-methylpropan-2-ylcarbamate 
• 1231958-24-9 (S)-tert-butyl 3-(4-chlorophenyl)-3-(2-(1,1,1-trifluoro-2-methylpropan-2-amine)ethyl)piperidine-1-carboxylate 
• 1124216-35-8 3-(chloromethyl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)benzamide 

Relevant articles and documents

Facile synthesis of 1,1-gem-dialkylperfluoroalkylamines

Tertiary 1,1-gem-dialkylperfluoroalkylamines were prepared by treatment of perfluoroalkylcarboxamides with alkylcerium chlorides, generated from cerium chloride and alkyllithium or alkyl Grignard reagents. The products were easily isolated as the hydrochl