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80-50-2

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  • 8-Azoniabicyclo[3.2.1]octane,8,8-dimethyl-3-[(1-oxo-2-propylpentyl)oxy]-, bromide, (3-endo)-

    Cas No: 80-50-2

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80-50-2 Usage

Description

Anisotropine Methylbromide, also known as Valpin, is a quaternary ammonium salt derived from the reaction of the amino group of anisotropine with methyl bromide. It is an anticholinergic agent with potential applications in the treatment of gastrointestinal disorders.

Uses

Used in Pharmaceutical Industry:
Anisotropine Methylbromide is used as an anticholinergic agent for the relief of gastrointestinal spasm and suppression of gastric acid secretion. Its anticholinergic properties help to reduce muscle contractions in the gastrointestinal tract, providing relief from spasms and cramps.
Used in Gastroenterology:
Anisotropine Methylbromide is used as a treatment for duodenal ulcer disease. Its ability to suppress gastric acid secretion and alleviate gastrointestinal spasms makes it a potentially useful agent in managing the symptoms and promoting healing of duodenal ulcers.

Originator

Valpin,Endo (Du Pont),US,1963

Manufacturing Process

Preparation of Di-n-propyl acetyl tropine hydrochloride: Tropine (11.12 grams) was dissolved in 100 ml of anhydrous pyridine and to this solution was added 15.64 grams of di-n-propyl acetyl chloride. The mixture was refluxed for 6 hours. This solution was then cooled and the pyridine removed in vacuum. The residue was dissolved in chloroform. The chloroform solution was washed with 10% hydrochloric acid to remove the residual trace of pyridine. The hydrochloride of the product ester is soluble in chloroform and is not extracted from chloroform by hydrochloric acid. This is an unexpected property. The chloroform solution of the hydrochloride was dried over anhydrous calcium sulfate, and evaporated to dryness, leaving a semisolid residue of product ester hydrochloride. This was recrystallized from chloroform-hexane mixture, MP 186°C. Preparation of the Anisotropine Methyl Bromide: To the acetone solution of the free base was added an acetone solution, containing an excess of methyl bromide. Within a few minutes the methobromide started to crystallize. The mixture was allowed to stand for several hours. The crystallized solid was filtered, and additional product was obtained by evaporation of the filtrate. The yield was nearly quantitative. After recrystallization from acetone, the product melted at 329°C.

Check Digit Verification of cas no

The CAS Registry Mumber 80-50-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 80-50:
(4*8)+(3*0)+(2*5)+(1*0)=42
42 % 10 = 2
So 80-50-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H32NO2.BrH/c1-5-7-13(8-6-2)17(19)20-16-11-14-9-10-15(12-16)18(14,3)4;/h13-16H,5-12H2,1-4H3;1H/q+1;/p-1

80-50-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name anisotropine methylbromide

1.2 Other means of identification

Product number -
Other names Anisotropine methylbromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80-50-2 SDS

80-50-2Upstream product

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