80-32-0 Usage
Description
Sulfachloropyridazine, a sulfonamide antibiotic, is an antibacterial compound with anti-inflammatory properties. It is commonly used in the treatment of acute urinary tract infections in children and has been selected as an ingredient for antibacterial compositions due to its antibiotic activity. Additionally, it can be introduced into drinking water to create aqueous liquid formulations for combating bacterial and protozoal infections in animals. Sulfachloropyridazine can also act as an eco-friendly inhibitor for corrosion of mild steel in H2SO4 solution and has been demonstrated to function as an anti-stress agent in poultry after vaccinations when associated with tripelennamine hydrochloride.
Uses
Used in Pharmaceutical Industry:
Sulfachloropyridazine is used as an antibacterial and anti-inflammatory drug for the treatment of acute urinary tract infections in children.
Used in Veterinary Medicine:
Sulfachloropyridazine is used as an antibacterial compound in the preparation of antibacterial compositions for combating bacterial and protozoal infections in animals.
Used in Corrosion Inhibition:
Sulfachloropyridazine is used as an eco-friendly inhibitor for corrosion of mild steel in H2SO4 solution.
Used in Poultry Industry:
Sulfachloropyridazine, when associated with tripelennamine hydrochloride, is used as an anti-stress agent in poultry after vaccinations.
Brand Names:
In the US, the brand name for Sulfachloropyridazine is Vetisulid. Other brand names include Nefrosul (3M Pharmaceuticals), Sonilyn (Carter-Wallace), and Vetisulid [Veterinary] (Fort Dodge Animal Health).
Reference
Stolar, M. E., Synergistic antibacterial composition US Patent 4470978 1984.
Gerhard Lukas; Atasoy, K., Aqueous liquid formulations for control of bacterial and protozoal diseases US Patent 4423043 1983.
Omar A. Hazazi; Ahmed Fawzy; Awad, M. I., Sulfachloropyridazine as an Eco-Friendly Inhibitor for Corrosion of Mild Steel in H2SO4 Solution Chemical Science Review and Letters 2015, 4, 67-79.
M. Nakano; M.N. Narimatsu; Portugal, M. A. S. C., Use of sulfachloropyridazine associated to tripelennamine hydrochloride as anti-stress agent in poultry after vaccinations. Biologico 1977.
Originator
Sonilyn,Mallinckrodt Inc.,US,1962
Manufacturing Process
1.9 parts of 3,6-dichloropyridazine, 3.4 parts of sulfanilamide, 2.7 parts of
potassium carbonate and 1 part of sodium chloride were ground together. The
solid mixture was heated with stirring and as the dichloropyridazine and
sulfanilamide melted, the mixture became a slurry. When the bath
temperature had reached 140°C a sudden evolution of carbon dioxide
occurred which lasted about 5 minutes, after which the mixture set in fine
granules. When no more carbon dioxide was evolved, heating was stopped
and the reaction mixture was heated with sufficient water to dissolve it and
the solution allowed to cool. Unreacted sulfanilamide was collected by
filtration. Excess dichloropyridazine was removed from the filtrate by
extraction with a water immiscible organic solvent such as ether.The basic solution was chilled and poured into one-half volume of 1:3 acetic
acid. Sufficient hydrochloric acid was added to bring the mixture to pH 4. The
crude 3-sulfanilamido-6-chloropyridazine which precipitated was purified by
solution in 6 parts of 1:100 ammonium hydroxide, charcoal treatment and
precipitation by pouring of the filtrate into dilute acetic acid.
Therapeutic Function
Antibacterial
Check Digit Verification of cas no
The CAS Registry Mumber 80-32-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 80-32:
(4*8)+(3*0)+(2*3)+(1*2)=40
40 % 10 = 0
So 80-32-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)
80-32-0Relevant articles and documents
Process for formulating a synthetic drug for use in animal feed, and resulting formulation
-
, (2008/06/13)
A method of formulating a synthetic drug for use in animal feed, for the purpose of reducing carry-over of the synthetic drug to subsequent lots of animal feed in the feed mill.
