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80-21-7

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80-21-7 Usage

Description

3-Aminobenzenesulfonanilide, also known as 3-Aminobenzenesulfonanilide or 3-Aminobenzenesulfonanilide, is an organic compound belonging to the sulfonamides class. It has the chemical formula C12H12N2O2S2 and is characterized by its white to light yellow crystalline powder form. 3-Aminobenzenesulfonanilide is sparingly soluble in water and slightly soluble in ethanol, and it exhibits reasonable stability under normal conditions, although it should be stored away from strong oxidizing agents and in a cool, dry place.

Uses

Used in Pharmaceutical Industry:
3-Aminobenzenesulfonanilide is used as an intermediate in the synthesis of various pharmaceuticals due to its chemical properties and reactivity. Its role in the production of drugs is significant, contributing to the development of new medications.
Used in Dye Production:
In the dye industry, 3-Aminobenzenesulfonanilide serves as an important intermediate. Its chemical structure allows for the creation of a range of dyes with specific color properties, making it valuable for various applications requiring colorants.
Used in Antimicrobial Applications:
Given its classification within the sulfonamides, 3-Aminobenzenesulfonanilide exhibits antimicrobial properties. It can be utilized in applications where resistance to microbial growth is necessary, such as in certain medical or industrial settings.

Check Digit Verification of cas no

The CAS Registry Mumber 80-21-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 0 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 80-21:
(4*8)+(3*0)+(2*2)+(1*1)=37
37 % 10 = 7
So 80-21-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H12N2O2S/c13-10-5-4-8-12(9-10)17(15,16)14-11-6-2-1-3-7-11/h1-9,14H,13H2

80-21-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Amino-N-phenylbenzenesulfonamide

1.2 Other means of identification

Product number -
Other names 3-amino-N-phenylbenzenesulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80-21-7 SDS

80-21-7Relevant articles and documents

Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27

Blavier, Jeremy,Charles, Ma?lle,Hanson, Julien,Kronenberger, Thales,Laschet, Céline,Müller, Christa E.,Pillaiyar, Thanigaimalai,Rosato, Francesca,Wozniak, Monika

, (2021/08/27)

GPR27 belongs, with GPR85 and GPR173, to a small subfamily of three receptors called “Super-Conserved Receptors Expressed in the Brain” (SREB). It has been postulated to participate in key physiological processes such as neuronal plasticity, energy metabolism, and pancreatic β-cell insulin secretion and regulation. Recently, we reported the first selective GPR27 agonist, 2,4-dichloro-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (I, pEC50 6.34, Emax 100%). Here, we describe the synthesis and structure-activity relationships of a series of new derivatives and analogs of I. All products were evaluated for their ability to activate GPR27 in an arrestin recruitment assay. As a result, agonists were identified with a broad range of efficacies including partial and full agonists, showing higher efficacies than the lead compound I. The most potent agonist was 4-chloro-2,5-difluoro-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (7y, pEC50 6.85, Emax 37%), and the agonists with higher efficacies were 4-chloro-2-methyl-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (7p, pEC50 6.04, Emax 123%), and 2-bromo-4-chloro-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (7r, pEC50 5.99, Emax 123%). Docking studies predicted the putative binding site and interactions of agonist 7p with GPR27. Selected potent agonists were found to be soluble and devoid of cellular toxicity within the range of their pharmacological activity. Therefore, they represent important new tools to further characterize the (patho)physiological roles of GPR27.

Synthesis and anticandidal activity of azole-containing sulfonamides

Qandil, Amjad M.,Hassan, Mohammad A.,Al-Shar'i, Nizar A.

experimental part, p. 99 - 112 (2009/04/03)

Twenty five benzenesulfonamides containing one imidazole or triazole ring, or two imidazole or triazole rings have been synthesized and evaluated as anticandidal agents. The most active compounds were 5c, 6b, 6c, 6e, and 17b, which exhibited MIC values of 4.55-24.39 mM depending on the clinical isolate. Comparing imidazole to triazole derivatives did not show a clear effect on activity. Compounds containing a N-benzyl group also showed no clear evidence on activity given the fact that they have an extra aromatic ring. Secondary sulfonamides, 5l, 5m, and 5n showed activities that were proportional to their lipophilicity. The activities of N-aryl-substituted derivatives 5j, 5k, 5l, 5m, 5n, and 6j were also proportional to their lipophilicity. Halogenation enhanced the activity as a result of improvement of lipophilicity. The presence of two imidazole or triazole rings in the same compound did not show a clear enhancement of activity.

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