79660-72-3 Usage
Description
Fleroxacin is a once-daily trifluoroquinolone antibacterial agent that is structurally related to norfloxacin. It is available in both oral and intravenous formulations and is known for its longer serum half-life of 9-12 hours compared to other drugs in its class, such as ciprofloxacin, enoxacin, and norfloxacin.
Uses
Used in Antibacterial Applications:
Fleroxacin is used as an antibiotic for the treatment of various bacterial infections, including gonorrhea, bacterial enteritis, chronic bronchitis, and urinary tract infections. Its longer serum half-life allows for once-daily dosing, making it a convenient option for patients.
Used in Pharmaceutical Industry:
Fleroxacin is used as a broad-spectrum antibiotic in the pharmaceutical industry for the development of medications to combat a wide range of bacterial infections. Its unique structural properties and extended half-life make it a valuable asset in the fight against antibiotic-resistant bacteria.
Manufacturing Process
6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-
oxoquinoline-3-carboxylic acid hydrochloride:A mixed solution of 1-methylpiperazine (0.34 g) and pyridine (3 ml) was
added to 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3-
carboxylic acid (0.12 g) and heated to reflux for 6 hours. After the solvent
evaporated and cooled, the residue was adjusted to pH 1 with aqueous
hydrochloric acid. The cooled mixture was filtered off and the solid
recrystallized from water to give 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-
(4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (0.08
g), melting point 269-271°C (decomp.).
Therapeutic Function
Antibacterial
Check Digit Verification of cas no
The CAS Registry Mumber 79660-72-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,6,6 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 79660-72:
(7*7)+(6*9)+(5*6)+(4*6)+(3*0)+(2*7)+(1*2)=173
173 % 10 = 3
So 79660-72-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
79660-72-3Relevant articles and documents
NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES
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Page/Page column 6; 8-9, (2009/04/24)
The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): in which R1, R2, R3, R4, R5, R6, R7, and X are as defined in Claim 1.
A process for the preparation of quinoline carboxylic acid derivatives
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, (2008/06/13)
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Quinoline carboxylic acid derivatives and process for the preparation
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, (2008/06/13)
This invention relates to new compounds of value as antibacterial agent. More particularly, it relates to quinoline carboxylic acid derivatives, the hydrates and the salts thereof.