78317-83-6

Basic information

• Product Name: Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-
• Synonyms: N-PMP-1,2,3,4-tetrahydroisoquinoline;N-p-methoxyphenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 78317-83-6
• Molecular Formula: C16H17NO
• Molecular Weight: 239.317
• Mol File: 78317-83-6.mol
• Article Data: 61

Chemical Properties

• Melting Point: 91-94°C
• CAS DataBase Reference: Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-(78317-83-6)
• EPA Substance Registry System: Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-(78317-83-6)

Safety Data

• Hazardous Substances Data: 78317-83-6(Hazardous Substances Data)

Usage

Description

Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)is a chemical compound belonging to the isoquinoline family. It is characterized by its unique molecular structure, which features a 1,2,3,4-tetrahydroisoquinoline core with a 4-methoxyphenyl group attached at the 2-position. Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)is known for its potential applications in various chemical and pharmaceutical processes.

Uses

Used in Chemical Synthesis:
Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)is used as a reagent in the gold-catalyzed preparation of indoletetrahydroisoquinolines. This application takes advantage of the compound's unique structure and reactivity, enabling the synthesis of complex organic molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
Isoquinoline, 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)may also find use in the pharmaceutical industry as a building block for the development of new drugs. Its unique structure and functional groups can be utilized in the design and synthesis of novel therapeutic agents, potentially leading to the discovery of new treatments for various diseases and conditions.

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 18649-43-9 4-methoxyphenyllead(IV) triacetate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 696-62-8 para-iodoanisole 
• 850130-96-0 2-(4-methoxyphenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline 
• 102-96-5 (2-nitroethenyl)benzene 
• 100-52-7 benzaldehyde 
• 64-04-0 phenethylamine 
• 100-66-3 methoxybenzene 
• 105728-90-3 2-fluoro-5-methoxybenzaldehyde 
• 356531-15-2 N-(4-methoxyphenyl)-2-bromobenzylamine 
• 6630-33-7 ortho-bromobenzaldehyde 
• 104-94-9 4-methoxy-aniline 
• 38018-60-9 (E/Z)-2-bromo-4'-methoxystilbene 

Downstream Products

• 850130-96-0 2-(4-methoxyphenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline 
• 1048958-15-1 1-(4-methoxyphenyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1048958-16-2 1-(biphenyl-4-yl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1048958-18-4 2-(4-methoxyphenyl)-1-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline 
• 1048958-20-8 1-(4-tert-butylphenyl)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1048958-17-3 1-(4-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phenyl)ethanone 
• 1048958-14-0 1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1141447-85-9 1-[1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-1-isoquinolinyl]hexan-2-one 
• 1141447-88-2 2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethan-1-one 
• 1141447-90-6 2-[1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-1-isoquinolinyl]-1-p-tolylethanone 
• 1141447-82-6 1-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-propan-2-one 
• 1141447-92-8 2-[1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-1-isoquinolinyl]-1-(4-methoxyphenyl)ethanone 
• 1150587-84-0 2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone 

Relevant articles and documents

Direct Near Infrared Light–Activatable Phthalocyanine Catalysts

The high penetration of near-infrared (NIR) light makes it effective for use in selective reactions under light-shielded conditions, such as in sealed reactors and deep tissues. Herein, we report the development of phthalocyanine catalysts directly activa

A Short Approach to N -Aryl-1,2,3,4-tetrahydroisoquinolines from N -(2-Bromobenzyl)anilines via a Reductive Amination/Palladium-Catalyzed Ethoxyvinylation/Reductive N -Alkylation Sequence

N -Aryl-1,2,3,4-tetrahydroisoquinolines are obtained via a convenient and short protocol with a broad range of substituents on both aromatic rings and high functional group tolerance. Starting from readily available ortho -brominated aromatic aldehydes and primary aromatic amines, condensation of these building blocks under reductive conditions gives N -aryl 2-bromobenzylamines. The C-3/C-4-unit of the tetrahydroisoquinoline is introduced using commercially available 2-ethoxyvinyl pinacolboronate under Suzuki conditions. Finally, the obtained crude ortho -ethoxyvinyl benzylamines are cyclized via an intramolecular reductive amination using the combination of triethylsilane/TFA to give the desired N -aryl-1,2,3,4-tetrahydroisoquinolines.

Porphyrin-Catalyzed Oxidation of N-Substituted Tetrahydroisoquinolines to Dihydroisoquinolones

A visible-light-induced direct α-oxygenation of N-substituted 1,2,3,4-Tetrahydroisoquinoline derivatives has been successfully developed. Tetraphenylporphyrinatozinc(II) has been identified as an effective and inexpensive photocatalyst for this transformation with a wide range of substrates. This protocol provides a convenient route to the desired products in moderate to good yields at room temperature under air.