78281-02-4 Usage
Biological Activity
Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities. It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 μM.
in vivo
Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats. It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral is chemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.
Check Digit Verification of cas no
The CAS Registry Mumber 78281-02-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,2,8 and 1 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 78281-02:
(7*7)+(6*8)+(5*2)+(4*8)+(3*1)+(2*0)+(1*2)=144
144 % 10 = 4
So 78281-02-4 is a valid CAS Registry Number.
InChI:InChI=1/C27H32O16/c28-7-11-16(32)25(43-26(40)17(11)33)27(41)23(38)14(12(31)6-3-9-1-4-10(30)5-2-9)19(35)15(24(27)39)22-21(37)20(36)18(34)13(8-29)42-22/h1-6,11,13,16-18,20-22,25-26,28-30,32-34,36-41H,7-8H2/b6-3+/t11-,13-,16-,17+,18-,20+,21-,22+,25+,26+,27?/m1/s1