78218-09-4

Basic information

• Product Name: Dazoxiben
• Synonyms: BENZOIC ACID, 4-[2-(1H-IMIDAZOL-1-YL)ETHOXY]-;4-[2-(1H-lmidazol-1-yl)ethoxyl]benzoic acid;4-[2-(1H-Imidazol-1-y1)ethoxy]benzoic acid;UK-37;AH-P719;4-(2-(1-Imidazolyl)ethoxy)benzoesaeure;74226-22-5 (Hydrochloride);Dazoxiben [inn:ban]
• CAS NO: 78218-09-4
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.24
• Mol File: 78218-09-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 230-235°C
• Boiling Point: 491.2 °C at 760 mmHg
• Flash Point: 250.9 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 1.83E-10mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Dazoxiben(CAS DataBase Reference)
• NIST Chemistry Reference: Dazoxiben(78218-09-4)
• EPA Substance Registry System: Dazoxiben(78218-09-4)

Safety Data

• Hazardous Substances Data: 78218-09-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16)

Upstream product

• 41386-38-3 4-(2-Bromo-ethoxy)-benzoic acid ethyl ester 
• 78712-84-2 4-(2-Imidazol-1-yl-ethoxy)-benzoic acid ethyl ester 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 56850-91-0 methyl 4-(2-bromoethoxy)benzoate 
• 288-32-4 1H-imidazole 
• 51616-09-2 4-(β-bromoethoxy)benzoic acid 

Downstream Products

• 75912-92-4 N-Methylsulphonyl-4-[2-(1-imidazolyl)ethoxy]benzenecarboximidic acid 
• 75912-92-4 N-methylsulphonyl-4-[2-(1-imidazolyl)ethoxy]benzenecarboxamidic acid 
• 75912-81-1 N-[4-(2-imidazol-1-yl)ethoxybenzoyl]morpholine 
• 102828-09-1 3-ethyl 5-[2-[4-[2-(1-imidazolyl)-ethoxy]-benzoyloxy]-ethyl]2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives

The structure-activity relationships of imidazole derivatives as inhibitors of thromboxane (TX) synthetase were investigated. Introduction of various substituents (e.g., one or two methyl groups, a halogen atom, a methylidene group, unsaturated bonds, or a phenylene group) into the α position or other positions in the carboxy-bearing side chain of 1-(7-carboxyheptyl)imidazole was found to increase the inhibitory potency. The length of the side chains with the phenylene group was optimum for the inhibitory potency on TX synthetase in the region of 8.5-9.0 A. Among the tested imidazole derivatives, 1-(7-carboxy-7-methyl-2-octynyl)imidazole, 4-[3-(1-imidazolyl)-propyl]benzoic acid, and (E)-4-(1-imidazolylmethyl)cinnamic acid and its α-methyl analogue showed the highest potency with an IC50 in the range of 10-8 to 10-9 M. Inhibition by these derivatives was highly selective for the TX synthetase, since other enzymes such as fatty acid cyclo-oxygenase and prostacyclin synthetase were not affected.